Journal article
Biotin catabolism is accelerated in adults receiving long-term therapy with anticonvulsants
Neurology, Vol.49(5), pp.1444-1447
11/1997
DOI: 10.1212/WNL.49.5.1444
PMID: 9371938
Abstract
Using serum biotin concentration as the indicator, a previous study reported biotin deficiency resulting from long-term anticonvulsant therapy. However, serum biotin may not be a good indicator of tissue biotin status. Using better indicators of biotin status in anticonvulsant-treated subjects, we found increased urinary excretion of biotin catabolites and 3-hydroxyisovaleric acid, an organic acid produced in greater quantities secondary to reduced activity of a biotin-dependent carboxylase. We conclude that anticonvulsant treatment led to increased biotin catabolism and probably to reduced biotin status.
Details
- Title: Subtitle
- Biotin catabolism is accelerated in adults receiving long-term therapy with anticonvulsants
- Creators
- Donald M MockMark E Dyken
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.49(5), pp.1444-1447
- DOI
- 10.1212/WNL.49.5.1444
- PMID
- 9371938
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Language
- English
- Date published
- 11/1997
- Academic Unit
- Neurology
- Record Identifier
- 9984020872602771
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