Journal article
Bipolar I: A Five-Year Prospective Follow-up
The journal of nervous and mental disease, Vol.181(4), pp.238-245
04/1993
DOI: 10.1097/00005053-199304000-00005
PMID: 8097229
Abstract
We explored the course of bipolar I illness in 172 probands who were followed up prospectively for up to 5 years. Probands were grouped into three categories based on whether the symptoms of the index episode were only depressed, only manic, or mixed/cycling. Data were available for recovery from the index episode, subsequent relapse, and rates of recovery from the first prospective episode. Pure manic probands had a significantly faster rate of recovery (median, 6 weeks) than the mixed/cycling probands (median, 17 weeks), and the pure depressive probands had an intermediate rate (median, 11 weeks). After 5 years of follow-up the mixed/cycling patients continue to have the lowest cumulative probability of recovery from the index episode. Mixed/cycling probands also had a substantially faster time to relapse after recovery from the index episode compared with pure manic patients. For those patients who relapsed, the mixed/cycling patients had the lowest cumulative probability of recovery from the first prospectively observed episode. The treatment received by these patients is described and there is a discussion of how this treatment may have influenced the findings on course and outcome.
Details
- Title: Subtitle
- Bipolar I: A Five-Year Prospective Follow-up
- Creators
- MARTIN KELLER - 1From the Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island 02906 2From the Department of Psychiatry, University of Iowa, Iowa City, Iowa 52242 3From the Department of Research and Training, New York State Psychiatric Institute, New York, New York 10032PHILIP LAVORIWILLIAM CORYELLJEAN ENDICOTTTIMOTHY MUELLER
- Resource Type
- Journal article
- Publication Details
- The journal of nervous and mental disease, Vol.181(4), pp.238-245
- Publisher
- Williams & Wilkins
- DOI
- 10.1097/00005053-199304000-00005
- PMID
- 8097229
- ISSN
- 0022-3018
- eISSN
- 1539-736X
- Language
- English
- Date published
- 04/1993
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003978102771
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