Journal article
Bipolar disorder in the balance
European archives of psychiatry and clinical neuroscience, Vol.269(7), pp.761-775
10/01/2019
DOI: 10.1007/s00406-018-0935-x
PMID: 30083956
Abstract
Bipolar disorder (BD) is a severe mood disorder that lacks established electrophysiological, neuroimaging or biological markers to assist with both diagnosis and monitoring disease severity. This study's aim is to describe the potential of new neurophysiological features assistive in BD diagnosis and severity measurement utilizing the recording of electrical activity from the outer ear canal called Electrovestibulography (EVestG). From EVestG data sensory vestibulo-acoustic features were extracted from a single supine-vertical translation stimulus to distinguish 50 depressed and partly remitted/remitted bipolar disorder patients [18 symptomatic (BD-S, MADRS > 19), 32 reduced symptomatic (BD-R, MADRS <= 19)] and 31 age and gender matched healthy individuals (controls). Six features were extracted from the measured firing pattern interval histogram and the extracted shape of the average field potential response. Five of the six features had low but significant correlations (p < 0.05) with the MADRS assessment. Using leave-one-out-cross-validation, unbiased parametric and non-parametric classification routines resulted in 75-79%, 84-86%, 76-85% and 79-82% accuracy for separation of control from BD, BD-S and BD-R as well as BD-S from BD-R groups, respectively. The main limitation of this study was the inability to fully disentangle the impact of prescribed medication from the responses recorded. A mix of stationary and movement evoked EVestG features produced good discrimination between control and BD patients whether BD-S or BD-R. Moreover, BD-S and BD-R appear to have measurably different pathophysiological manifestations. The firing pattern features used were dissimilar to those observed in a prior major depressive disorder study.
Details
- Title: Subtitle
- Bipolar disorder in the balance
- Creators
- Brian J. Lithgow - Monash Alfred Psychiatry Research centreZahra Moussavi - University of ManitobaCaroline Gurvich - Monash Alfred Psychiatry Research centreJayashri Kulkarni - Monash Alfred Psychiatry Research centreJerome J Maller - Monash UniversityPaul B. Fitzgerald - Monash Alfred Psychiatry Research centre
- Resource Type
- Journal article
- Publication Details
- European archives of psychiatry and clinical neuroscience, Vol.269(7), pp.761-775
- DOI
- 10.1007/s00406-018-0935-x
- PMID
- 30083956
- NLM abbreviation
- Eur Arch Psychiatry Clin Neurosci
- ISSN
- 0940-1334
- eISSN
- 1433-8491
- Publisher
- Springer Nature
- Number of pages
- 15
- Grant note
- LP0669420 / Australian Research Council
- Language
- English
- Date published
- 10/01/2019
- Academic Unit
- Radiology
- Record Identifier
- 9984848506402771
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