Journal article
Birth Outcomes Related to Prenatal Zika, Dengue, and Other Flavivirus Infections in the Zika en Embarazadas y Niños Prospective Cohort Study in Colombia
The American journal of tropical medicine and hygiene, Vol.111(3), pp.622-626
07/09/2024
DOI: 10.4269/ajtmh.23-0873
PMCID: PMC11376175
PMID: 38981499
Abstract
Zika virus (ZIKV) infection in pregnancy is associated with severe abnormalities of the brain and eye and other adverse outcomes. Zika en Embarazadas y Niños was a prospective cohort study conducted in multiple Colombian cities that enrolled pregnant women in their first trimester. Specimens collected from pregnant women ( n = 1,519) during February 2017–September 2018 and their infants ( n = 1,080) during June 2017–March 2019 were tested for prenatal ZIKV infection by nucleic acid amplification tests or IgM antibody testing. Zika virus infection in pregnancy was present in 3.2% of pregnant women (incidence rate [IR] per 1,000 person-months = 5.9, 95% CI: 4.3–7.8). Presumptive ZIKV infection was present in 0.8% of infants (IR = 1.6, 95% CI: 0.7–2.9). Five percent of infants with prenatal ZIKV exposure or infection presented with Zika-associated abnormalities; 4.7% were small for gestational age. Understanding the risk of ZIKV infection during pregnancy and associated adverse outcomes can help inform counseling efforts.
Details
- Title: Subtitle
- Birth Outcomes Related to Prenatal Zika, Dengue, and Other Flavivirus Infections in the Zika en Embarazadas y Niños Prospective Cohort Study in Colombia
- Creators
- Ayzsa Tannis - National Center on Birth Defects and Developmental DisabilitiesSuzanne Newton - National Center on Birth Defects and Developmental DisabilitiesAngelica Rico - Division of Research in Public Health, National Institute of Health, Bogota, ColombiaMaritza Gonzalez - Division of Research in Public Health, National Institute of Health, Bogota, ColombiaMonica Benavides - Maternal and Perinatal Research Division, National Institute of Health, Bogota, ColombiaJessica N. Ricaldi - National Center for Emerging and Zoonotic Infectious DiseasesHelena Rodriguez - Division of Research in Public Health, National Institute of Health, Bogota, ColombiaLaura D. Zambrano - Centers for Disease Control and PreventionMarcela Daza - Maternal and Perinatal Research Division, National Institute of Health, Bogota, ColombiaShana Godfred-Cato - National Center on Birth Defects and Developmental DisabilitiesJennifer D. Thomas - National Center for Emerging and Zoonotic Infectious DiseasesJacqueline Acosta - Research Division, Vysnova Partners, Bethesda, MarylandPanagiotis Maniatis - National Center for Immunization and Respiratory DiseasesJonathan B. Daniels - Office of Readiness and ResponseVeronica Burkel - National Center on Birth Defects and Developmental DisabilitiesElizabeth C. Ailes - National Center on Birth Defects and Developmental DisabilitiesDiana Valencia - National Center for Emerging and Zoonotic Infectious DiseasesSuzanne M. Gilboa - Centers for Disease Control and PreventionDenise J. Jamieson - University of IowaMarcela Mercado - Maternal and Perinatal Research Division, National Institute of Health, Bogota, ColombiaJulie M. Villanueva - Centers for Disease Control and PreventionMargaret A. Honein - Centers for Disease Control and PreventionMartha L. Ospina - Florida International UniversityVan T. Tong - Centers for Disease Control and Prevention
- Resource Type
- Journal article
- Publication Details
- The American journal of tropical medicine and hygiene, Vol.111(3), pp.622-626
- DOI
- 10.4269/ajtmh.23-0873
- PMID
- 38981499
- PMCID
- PMC11376175
- NLM abbreviation
- Am J Trop Med Hyg
- ISSN
- 0002-9637
- eISSN
- 1476-1645
- Publisher
- AMER SOC TROP MED & HYGIENE
- Grant note
This research was made possible through support provided by the CDC, the INS, and the Office of Infectious Disease, Bureau for Global Health, USAID under the terms of an Interagency Agreement with the CDC. A Memorandum of Understanding between the CDC and the INS was signed in August 2016 to support areas of collaboration including public health surveillance, epidemiology, laboratory screening and diagnosis, vector control, and other public health response activities for the ZIKV outbreak. The work was implemented through contract numbers 200-2016-91589 and 200-2017-95780 to Vysnova Partners, Inc.
- Language
- English
- Electronic publication date
- 07/09/2024
- Academic Unit
- Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984654464102771
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