Birth and early developmental screening outcomes associated with cannabis exposure during pregnancy

Elyse Olshen Kharbanda; Gabriela Vazquez-Benitez; Alicia Kunin-Batson; James D Nordin; Avalow Olsen; Paul A Romitti

doi:10.1038/s41372-019-0576-6

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Birth and early developmental screening outcomes associated with cannabis exposure during pregnancy

Journal article

Peer reviewed

Birth and early developmental screening outcomes associated with cannabis exposure during pregnancy

Elyse Olshen Kharbanda, Gabriela Vazquez-Benitez, Alicia Kunin-Batson, James D Nordin, Avalow Olsen and Paul A Romitti

Journal of perinatology, Vol.40(3), pp.473-480

03/2020

DOI: 10.1038/s41372-019-0576-6

PMCID: PMC7047636

PMID: 31911642

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https://www.ncbi.nlm.nih.gov/pmc/articles/7047636View

Open Access

Abstract

To compare birth and early developmental screening outcomes for infants with and without in utero cannabis exposures. Observational cohort of women receiving prenatal care within a large health system, live birth between October 1, 2015 and December 1, 2017, and at least one infant visit. Cannabis exposure was through routine urine toxicology screen. Preterm birth, small for gestational age (SGA) birth, birth defects, and early developmental screening outcomes were assessed from birth and electronic health record data. Of 3435 women, 283 (8.2%) had a positive urine toxicology screen. In utero cannabis exposure was associated with SGA birth, adjusted rate ratio (aRR) 1.69 (95% confidence interval [CI]: 1.22-2.34). Abnormal 12-month developmental screens occurred in 9.1% of infants with in utero cannabis exposure vs. 3.6% of those with negative maternal screens, aRR 1.90 (95% CI: 0.92-3.91). Additional birth outcomes were not associated with in utero cannabis exposure. Exposure to cannabis during pregnancy may adversely impact fetal growth.

Cannabis - adverse effects

Cohort Studies

Electronic Health Records

Female

Fetal Development - drug effects

Humans

Infant

Infant, Low Birth Weight

Infant, Newborn

Infant, Small for Gestational Age

Male

Marijuana Abuse

Pregnancy

Premature Birth - epidemiology

Prenatal Care

Details

Title: Subtitle: Birth and early developmental screening outcomes associated with cannabis exposure during pregnancy
Creators: Elyse Olshen Kharbanda - HealthPartners Institute, Bloomington, MN, USA. Elyse.O.Kharbanda@healthpartners.com
Gabriela Vazquez-Benitez - HealthPartners Institute, Bloomington, MN, USA
Alicia Kunin-Batson - Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
James D Nordin - HealthPartners Institute, Bloomington, MN, USA
Avalow Olsen - HealthPartners Institute, Bloomington, MN, USA
Paul A Romitti - Department of Epidemiology, University of Iowa, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.40(3), pp.473-480
DOI: 10.1038/s41372-019-0576-6
PMID: 31911642
PMCID: PMC7047636
NLM abbreviation: J Perinatol
ISSN: 0743-8346
eISSN: 1476-5543
Grant note: U01 DD001035 / NCBDD CDC HHS U01DD001035 / ACL HHS U01 DD001223 / NCBDD CDC HHS
Language: English
Date published: 03/2020
Academic Unit: Epidemiology; Biostatistics
Record Identifier: 9984214820802771

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