Birth weight discordance in very low birth weight twins: mortality, morbidity, and neurodevelopment

Nansi S Boghossian; Shampa Saha; Edward F Bell; Jane E Brumbaugh; Seetha Shankaran; Waldemar A Carlo; Abhik Das; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

doi:10.1038/s41372-019-0427-5

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Birth weight discordance in very low birth weight twins: mortality, morbidity, and neurodevelopment

Journal article

Peer reviewed

Birth weight discordance in very low birth weight twins: mortality, morbidity, and neurodevelopment

Nansi S Boghossian, Shampa Saha, Edward F Bell, Jane E Brumbaugh, Seetha Shankaran, Waldemar A Carlo, Abhik Das and Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

Journal of perinatology, Vol.39(9), pp.1229-1240

09/2019

DOI: 10.1038/s41372-019-0427-5

PMCID: PMC6713585

PMID: 31312035

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Abstract

Examine outcomes among birth weight concordant and discordant 401-1500 g twins. Twins (n = 8,114) at NICHD Neonatal Research Network (1994-2011) were studied. Discordance (birth weight difference/larger twin birth weight x 100%) was categorized into: ≤ 14, > 14-20, > 20-30, and > 30%. Separate logistic regression models for the smaller and larger infants assessed the adjusted association between discordance and outcomes. Compared with the smaller twin with ≤ 14% discordance, mortality, necrotizing enterocolitis, severe retinopathy of prematurity, bronchopulmonary dysplasia, and neurodevelopmental impairment or death were highest among the smaller twins with discordance > 30%. The larger twins with discordance > 30% had higher odds of patent ductus arteriosus, moderate-to-severe cerebral palsy, blindness, cognitive and motor scores < 70. Odds of cerebral palsy and blindness were also higher among the larger twins with discordance > 14-20%. Discordance > 30% was associated with higher mortality in the smaller twin and higher morbidities among the smaller and larger twins.

Adolescent

Adult

Birth Weight

Diseases in Twins - epidemiology

Female

Follow-Up Studies

Hospital Mortality

Humans

Infant

Infant Mortality

Infant, Newborn

Infant, Newborn, Diseases - epidemiology

Male

Maternal Age

Neurodevelopmental Disorders - epidemiology

Odds Ratio

Twins

Details

Title: Subtitle: Birth weight discordance in very low birth weight twins: mortality, morbidity, and neurodevelopment
Creators: Nansi S Boghossian - University of South Carolina
Shampa Saha - RTI International
Edward F Bell - University of Iowa
Jane E Brumbaugh - Mayo Clinic in Florida
Seetha Shankaran - Wayne State University
Waldemar A Carlo - University of Alabama at Birmingham
Abhik Das - RTI International
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.39(9), pp.1229-1240
DOI: 10.1038/s41372-019-0427-5
PMID: 31312035
PMCID: PMC6713585
ISSN: 0743-8346
eISSN: 1476-5543
Grant note: UG1 HD053109 / NICHD NIH HHS U10 HD021373 / NICHD NIH HHS U10 HD053109 / NICHD NIH HHS UG1 HD087226 / NICHD NIH HHS U01 HD036790 / NICHD NIH HHS U10 HD021385 / NICHD NIH HHS U24 HD095254 / NICHD NIH HHS UG1 HD034216 / NICHD NIH HHS UG1 HD087229 / NICHD NIH HHS U10 HD034216 / NICHD NIH HHS UG1 HD027853 / NICHD NIH HHS UG1 HD027880 / NICHD NIH HHS
Language: English
Date published: 09/2019
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984353800902771

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