Journal article
Bis-4-aminoquinolines: novel triple-helix DNA intercalators and antagonists of immunostimulatory CpG-oligodeoxynucleotides
Bioorganic & medicinal chemistry, Vol.11(6), pp.1079-1085
2003
DOI: 10.1016/S0968-0896(02)00525-4
PMID: 12614895
Abstract
Six dimeric 2-(2-naphthyl)quinolin-4-amines with a linker between the amino groups and eight dimeric 2-(4-anilino)quinolin-4-amines linked between the anilino groups were synthesized and evaluated for their interaction with duplex/triplex DNA's and as antagonists of immunostimulatory oligodeoxynucleotides with a CpG-motif (CpG-ODN). The most powerful triple-helix DNA intercalator known to date, with high affinity toward T·A·T triplets and triplex/duplex selectivity, was found. The potent antagonism of immunostimulatory CpG-ODN by several bis-4-aminoquinolines is not related to their DNA interactions.
Details
- Title: Subtitle
- Bis-4-aminoquinolines: novel triple-helix DNA intercalators and antagonists of immunostimulatory CpG-oligodeoxynucleotides
- Creators
- Lucjan Strekowski - Department of Chemistry, Georgia State University, Atlanta, GA 30303, USAMartial Say - Department of Chemistry, Georgia State University, Atlanta, GA 30303, USAOliwia Zegrocka - Department of Chemistry, Georgia State University, Atlanta, GA 30303, USAFarial A Tanious - Department of Chemistry, Georgia State University, Atlanta, GA 30303, USAW.David Wilson - Department of Chemistry, Georgia State University, Atlanta, GA 30303, USALori Manzel - Department of Medicine, Veterans Affairs Medical Center and University of Iowa, Iowa City, IA 52242, USADonald E Macfarlane - Department of Medicine, Veterans Affairs Medical Center and University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Bioorganic & medicinal chemistry, Vol.11(6), pp.1079-1085
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0968-0896(02)00525-4
- PMID
- 12614895
- ISSN
- 0968-0896
- eISSN
- 1464-3391
- Language
- English
- Date published
- 2003
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984094674402771
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