Bispectral EEG (BSEEG) to assess arousal after electro-convulsive therapy (ECT)

Kasra Zarei; Nicholas A Sparr; Nicholas T Trapp; Elena D Neuhaus; John W Cromwell; Aaron D Boes; Gen Shinozaki

doi:10.1016/j.psychres.2020.112811

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Bispectral EEG (BSEEG) to assess arousal after electro-convulsive therapy (ECT)

Journal article

Peer reviewed

Bispectral EEG (BSEEG) to assess arousal after electro-convulsive therapy (ECT)

Kasra Zarei, Nicholas A Sparr, Nicholas T Trapp, Elena D Neuhaus, John W Cromwell, Aaron D Boes and Gen Shinozaki

Psychiatry research, Vol.285, pp.112811-112811

03/2020

DOI: 10.1016/j.psychres.2020.112811

PMID: 32032823

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https://www.ncbi.nlm.nih.gov/pmc/articles/7605101View

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Abstract

The purpose of this study was to assess whether two-channel frontal electroencephalography activity could be used to assess arousal after electro-convulsive therapy. Frontal EEG has promise in objectively predicting arousal immediately after and recovery hours after electro-convulsive therapy. Postictal confusion is encountered among most patients following electro-convulsive therapy (ECT). This study aimed to test the capabilities of a point-of-care electroencephalography (EEG) method to quantitatively measure and monitor postictal confusion immediately following ECT. We evaluated whether a two-channel frontal EEG device may provide a purely quantitative measure of the postictal state that could aid in the continuous, clinical monitoring of patients following ECT. 50 patients receiving ECT at the University of Iowa Hospitals and Clinics were recruited for this study. Subsequently, we obtained 5 min of frontal bispectral EEG (BSEEG) recording from a hand-held EEG device at baseline and 10–20 min following ECT. We performed power spectral density analysis to yield a “BSEEG” score and to capture the difference between patients at baseline and after ECT. The BSEEG score was demonstrated to be a significant indicator of postictal confusion compared to baseline. For 5 patients, we also obtained continuous EEG recordings following ECT to determine the time course required for a patient's BSEEG score to return to baseline. In this subset of patients, it took between 2 and 3 h in duration for the BSEEG score to return to the baseline range. In this pilot study, we showed that BSEEG score was able to distinguish between baseline condition and postictal confusion in patients treated with ECT, and assess the duration for recovery from postictal confusion following ECT. BSEEG may provide a more sensitive measure of arousal in patients following ECT compared to traditional survey-based methods.

Electroencephalography

Delirium

Power spectral analysis

Computational psychiatry

Postictal confusion

Electro-convulsive therapy

Details

Title: Subtitle: Bispectral EEG (BSEEG) to assess arousal after electro-convulsive therapy (ECT)
Creators: Kasra Zarei - University of Iowa, Department of Psychiatry, USA
Nicholas A Sparr - University of Iowa, Department of Psychiatry, USA
Nicholas T Trapp - University of Iowa, Department of Psychiatry, USA
Elena D Neuhaus - University of Iowa, Department of Psychiatry, USA
John W Cromwell - University of Iowa, Department of Surgery, USA
Aaron D Boes - University of Iowa, Department of Psychiatry, USA
Gen Shinozaki - University of Iowa, Department of Psychiatry, USA
Resource Type: Journal article
Publication Details: Psychiatry research, Vol.285, pp.112811-112811
DOI: 10.1016/j.psychres.2020.112811
PMID: 32032823
NLM abbreviation: Psychiatry Res
ISSN: 0165-1781
eISSN: 1872-7123
Publisher: Elsevier B.V
Grant note: name: GS
Language: English
Date published: 03/2020
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Surgery; Anesthesia; Neurology (Pediatrics); Neurosurgery
Record Identifier: 9984070797602771

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