Journal article
Bisphenol F exposure in adolescent heterogeneous stock (HS) rats affects growth and adiposity
Toxicological sciences, Vol.181(2), pp.246-261
03/23/2021
DOI: 10.1093/toxsci/kfab035
PMID: 33755180
Abstract
Abstract Bisphenol F (BPF) is increasingly substituting bisphenol A (BPA) in manufacturing polycarbonates and consumer products. The cardiometabolic effects of BPF in either humans or model organisms are not clear, and no studies to date have investigated the role of genetic background on susceptibility to BPF-induced cardiometabolic traits. The primary goal of this project was to determine if BPF exposure influences growth and adiposity in male N: NIH Heterogeneous Stock (HS) rats, a genetically heterogeneous population. Littermate pairs of male HS rats were randomly exposed to either vehicle (0.1% Ethanol) or 1.125 µg/ml BPF in 0.1% Ethanol for five weeks in drinking water starting at three weeks-of-age. Water consumption and body weight was measured weekly, body composition was determined using nuclear magnetic resonance (NMR), urine and feces were collected in metabolic cages, and blood and tissues were collected at the end of the study. BPF-exposed rats showed significantly increased body growth and abdominal adiposity, risk factors for cardiometabolic disease. Urine output was increased in BPF-exposed rats, driving a trend in increased creatinine clearance. We also report the first relationship between a bisphenol metabolizing enzyme and a bisphenol-induced phenotype. Preliminary heritability estimates of significant phenotypes suggest that BPF exposure may alter trait variation. These findings support BPF exposure as a cardiometabolic disease risk factor and indicate that the HS rat will be a useful model for dissecting gene by BPF interactions on metabolic health.
Details
- Title: Subtitle
- Bisphenol F exposure in adolescent heterogeneous stock (HS) rats affects growth and adiposity
- Creators
- Valerie A Wagner - Department of Pharmacology, University of Iowa, Iowa City, IA, USA, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USAKaren C Clark - Department of Pharmacology, University of Iowa, Iowa City, IA, USA, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USALeslie Carrillo-Sáenz - Division of Endocrinology, Diabetes and Metabolism and Department of Physiology and Biophysics, University of Illinois at Chicago College of Medicine, Chicago, IL, USAKatie A Holl - Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USAMiriam Velez-Bermudez - Department of Psychological & Brain Sciences, University of Iowa, Iowa City, IA, USADerek Simonsen - Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, USAJustin L Grobe - Department of Pharmacology, University of Iowa, Iowa City, IA, USA, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA, Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, USA, Comprehensive Rodent Metabolic Phenotyping Core, Medical College of Wisconsin, Milwaukee, WI, USAKai Wang - Department of Biostatistics, University of Iowa, Iowa City, IA, USAAndrew Thurman - Department of Internal Medicine, University of Iowa, Iowa City, IA, USALeah C Solberg Woods - Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USAHans-Joachim Lehmler - Department of Occupational and Environmental Health, University of Iowa, Iowa City, IA, USAAnne E Kwitek - Department of Pharmacology, University of Iowa, Iowa City, IA, USA, Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA, Rat Genome Database, Medical College of Wisconsin, Milwaukee, WI, USA
- Resource Type
- Journal article
- Publication Details
- Toxicological sciences, Vol.181(2), pp.246-261
- DOI
- 10.1093/toxsci/kfab035
- PMID
- 33755180
- NLM abbreviation
- Toxicol Sci
- ISSN
- 1096-6080
- eISSN
- 1096-0929
- Grant note
- name: University of Iowa Environmental Health Sciences Research Center; DOI: 10.13039/100000002, name: NIH, award: P30ES005605; name: National Institutes of Health Predoctoral Training; DOI: 10.13039/100000002, name: NIH, award: T32GM008629; name: Mechanisms of Health and Disease at the Behavioral and Biomedical Interface Training Program; DOI: 10.13039/100000002, name: NIH, award: T32GM108540; name: National Institutes of Health Program Project; DOI: 10.13039/100000002, name: NIH, award: P01HL084207
- Language
- English
- Date published
- 03/23/2021
- Academic Unit
- Occupational and Environmental Health; Iowa Neuroscience Institute; Biostatistics; Internal Medicine
- Record Identifier
- 9984077378502771
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