Journal article
Biventricular adaptation after patent ductus arteriosus ligation
Pediatric research, Vol.99(5), pp.1664-1667
06/2026
DOI: 10.1038/s41390-025-04615-8
PMCID: PMC13221303
PMID: 41272299
Appears in UI Libraries Support Open Access
Abstract
Patent ductus arteriosus closure is followed by major adaptive changes in cardiac loading conditions, which may be associated with hemodynamic instability in some patients secondary to left ventricular systolic and diastolic dysfunction. Conventional echocardiography measures, including ejection fraction, have poor sensitivity for early detection of impaired left ventricular dysfunction. Speckle Tracking Echocardiography, which allows characterization of atrial and ventricular strain, may be an earlier and more sensitive marker of abnormal heart function. Recent guidelines suggest incorporation of speckle tracking echocardiography into multiparametric assessments of heart function in neonates. Its use may enhance clinical decision-making by improving early detection of dysfunction and enabling more accurate risk stratification following PDA closure.
Details
- Title: Subtitle
- Biventricular adaptation after patent ductus arteriosus ligation
- Creators
- Adrianne R Bischoff - University of IowaPatrick J McNamara - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.99(5), pp.1664-1667
- DOI
- 10.1038/s41390-025-04615-8
- PMID
- 41272299
- PMCID
- PMC13221303
- NLM abbreviation
- Pediatr Res
- ISSN
- 1530-0447
- eISSN
- 1530-0447
- Publisher
- Springer Nature
- Language
- English
- Electronic publication date
- 11/21/2025
- Date published
- 06/2026
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9985033760502771
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