Journal article
Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS
Respiratory research, Vol.23(1), pp.1-310
01/01/2022
DOI: 10.1186/s12931-022-02225-0
PMCID: PMC9664618
PMID: 36376879
Abstract
Background: Airway macrophages (AM), crucial for the immune response in chronic obstructive pulmonary disease (COPD), are exposed to environmental particulate matter (PM), which they retain in their cytoplasm as black carbon (BC). However, whether AM BC accurately reflects environmental PM2.5 exposure, and can serve as a biomarker of COPD outcomes, is unknown. Methods: We analyzed induced sputum from participants at 7 of 12 sites SPIROMICS sites for AM BC content, which we related to exposures and to lung function and respiratory outcomes. Models were adjusted for batch (first vs. second), age, race (white vs. non-white), income (<$35,000, $35,000~$74,999, ≥$75,000, decline to answer), BMI, and use of long-acting beta-agonist/long-acting muscarinic antagonists, with sensitivity analysis performed with inclusion of urinary cotinine and lung function as covariates. Results: Of 324 participants, 143 were current smokers and 201 had spirometric-confirmed COPD. Modeled indoor fine (< 2.5 μm in aerodynamic diameter) particulate matter (PM2.5) and urinary cotinine were associated with higher AM BC. Other assessed indoor and ambient pollutant exposures were not associated with higher AM BC. Higher AM BC was associated with worse lung function and odds of severe exacerbation, as well as worse functional status, respiratory symptoms and quality of life. Conclusion: Indoor PM2.5 and cigarette smoke exposure may lead to increased AM BC deposition. Black carbon content in AMs is associated with worse COPD morbidity in current and former smokers, which remained after sensitivity analysis adjusting for cigarette smoke burden. Airway macrophage BC, which may alter macrophage function, could serve as a predictor of experiencing worse respiratory symptoms and impaired lung function.
Details
- Title: Subtitle
- Black carbon content in airway macrophages is associated with increased severe exacerbations and worse COPD morbidity in SPIROMICS
- Creators
- Vickram Tejwani - Johns Hopkins UniversityHan Woo - Baltimore, MD USAChen Liu - Baltimore, MD USAAnna K. Tillery - Chapel Hill, NC USAAmanda J. Gassett - Seattle, WA USARichard E. Kanner - Salt Lake City, UT USAEric A. Hoffman - Iowa City, IA USAFernando J. Martinez - New York, NY USAPrescott G. Woodruff - San Francisco, CA USAR. Graham Barr - New York, New York, USAAshraf Fawzy - Baltimore, MD USAKirsten Koehler - Baltimore, MD USAJeffrey L. Curtis - Ann Arbor, MI USA Ann Arbor, MI USAChristine M. Freeman - Ann Arbor, MI USA Ann Arbor, MI USAChristopher B. Cooper - Los Angeles, CA USAAlejandro P. Comellas - Iowa City, IA USACheryl Pirozzi - Salt Lake City, UT USARobert Paine - Salt Lake City, UT USADonald Tashkin - Los Angeles, CA USAJerry A. Krishnan - Chicago, IL USACoralynn Sack - Seattle, WA USANirupama Putcha - Baltimore, MD USALaura M. Paulin - Lebanon, NH USAMarina Zusman - Seattle, WA USAJoel D. Kaufman - Seattle, WA USANeil E. Alexis - Chapel Hill, NC USANadia N. Hansel - Baltimore, MD USA
- Resource Type
- Journal article
- Publication Details
- Respiratory research, Vol.23(1), pp.1-310
- DOI
- 10.1186/s12931-022-02225-0
- PMID
- 36376879
- PMCID
- PMC9664618
- NLM abbreviation
- Respir Res
- ISSN
- 1465-9921
- eISSN
- 1465-993X
- Publisher
- BioMed Central
- Grant note
- F32HL149258-01 / ;
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984318724402771
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