Blanket temperature during therapeutic hypothermia and outcomes in hypoxic ischemic encephalopathy

John Flibotte; Abbot R. Laptook; Seetha Shankaran; Scott A. McDonald; Mariana C. Baserga; Edward F. Bell; C. Michael Cotten; Abhik Das; Sara B. DeMauro; Tara L. DuPont; Eric C. Eichenwald; Roy Heyne; Erik A. Jensen; Krisa P. Van Meurs; Kevin Dysart; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

doi:10.1038/s41372-021-01302-4

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Blanket temperature during therapeutic hypothermia and outcomes in hypoxic ischemic encephalopathy

Journal article

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Blanket temperature during therapeutic hypothermia and outcomes in hypoxic ischemic encephalopathy

John Flibotte, Abbot R. Laptook, Seetha Shankaran, Scott A. McDonald, Mariana C. Baserga, Edward F. Bell, C. Michael Cotten, Abhik Das, Sara B. DeMauro, Tara L. DuPont, …

Journal of perinatology, Vol.42(3), pp.348-353

01/08/2022

DOI: 10.1038/s41372-021-01302-4

PMCID: PMC9121861

PMID: 34999716

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https://www.ncbi.nlm.nih.gov/pmc/articles/9121861View

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Abstract

Objective Determine whether blanket temperatures during therapeutic hypothermia (TH) are associated with 18-22 month outcomes for infants with hypoxic ischemic encephalopathy (HIE). Study design Retrospective cohort study of 181 infants with HIE who received TH in two randomized trials within the Neonatal Research Network. We defined summative blanket temperature constructs and evaluated for association with a primary composite outcome of death or moderate/ severe disability at 18-22 months. Results Each 0.5 degrees C above 33.5 degrees C in the mean of the highest quartile blanket temperature was associated with a 52% increase in the adjusted odds of death/ disability (aOR 1.52, 95% CI 1.09-2.11). Having >8 consecutive blanket temperatures above 33.5 degrees C rendered an aOR of death/disability of 5.04 in the first 24 h (95% CI 1.54-16.6) and 6.92 in the first 48 h (95% CI 2.20-21.8) of TH. Conclusions Higher blanket temperature during TH may be an early, clinically useful biomarker of HIE outcome.

Pediatrics

Life Sciences & Biomedicine

Obstetrics & Gynecology

Science & Technology

Details

Title: Subtitle: Blanket temperature during therapeutic hypothermia and outcomes in hypoxic ischemic encephalopathy
Creators: John Flibotte - Children's Hospital of Philadelphia
Abbot R. Laptook - Brown University
Seetha Shankaran - Wayne State University
Scott A. McDonald - RTI International
Mariana C. Baserga - University of Utah
Edward F. Bell - University of Iowa
C. Michael Cotten - Duke University
Abhik Das - RTI International
Sara B. DeMauro - Children's Hospital of Philadelphia
Tara L. DuPont - University of Utah
Eric C. Eichenwald - University of Pennsylvania
Roy Heyne - The University of Texas Southwestern Medical Center
Erik A. Jensen - Children's Hospital of Philadelphia
Krisa P. Van Meurs - Stanford University
Kevin Dysart - Alfred I. duPont Hospital for Children
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.42(3), pp.348-353
DOI: 10.1038/s41372-021-01302-4
PMID: 34999716
PMCID: PMC9121861
NLM abbreviation: J Perinatol
ISSN: 0743-8346
eISSN: 1476-5543
Publisher: Springer Nature
Number of pages: 6
Grant note: Neonatal Research Network (NRN) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Language: English
Date published: 01/08/2022
Academic Unit: Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984353845302771

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