Journal article
Bletilla striata Polysaccharide Stimulates Inducible Nitric Oxide Synthase and Proinflammatory Cytokine Expression in Macrophages
Journal of bioscience and bioengineering, Vol.105(2), pp.85-89
2008
DOI: 10.1263/jbb.105.85
PMID: 18343332
Abstract
Bletilla striata, a traditional Chinese medicine, has been used for the treatment of alimentary canal mucosal damage, ulcers, bleeding, bruises and burns.
B. striata polysaccharide (BSP) isolated from
B. striata was found to enhance vascular endothelial cell (EC) proliferation and vascular endothelial growth factor (VEGF) expression. However, the wound healing mechanism of BSP is not well understood. In this study, the results show that treatment with BSP induces coordinate changes in inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) mRNA levels and enhances the expression of these cytokines, but has no effect on interferon gamma (IFN-γ) level. In this study, we partially elucidate the wound healing mechanism of BSP.
Details
- Title: Subtitle
- Bletilla striata Polysaccharide Stimulates Inducible Nitric Oxide Synthase and Proinflammatory Cytokine Expression in Macrophages
- Creators
- Huajia Diao - Nanjing UniversityXin Li - Nanjing UniversityJiangning Chen - Nanjing UniversityYi Luo - Nanjing UniversityXi Chen - Nanjing UniversityLei Dong - Nanjing UniversityChunming Wang - Nanjing UniversityChenyu Zhang - Nanjing UniversityJunfeng Zhang - Nanjing University
- Resource Type
- Journal article
- Publication Details
- Journal of bioscience and bioengineering, Vol.105(2), pp.85-89
- Publisher
- Elsevier B.V
- DOI
- 10.1263/jbb.105.85
- PMID
- 18343332
- ISSN
- 1389-1723
- eISSN
- 1347-4421
- Language
- English
- Date published
- 2008
- Academic Unit
- Urology
- Record Identifier
- 9984319980702771
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