Journal article
Blockade of Neurotransmission in Drosophila Mushroom Bodies Impairs Odor Attraction, but Not Repulsion
Current biology, Vol.13(21), pp.1900-1904
10/28/2003
DOI: 10.1016/j.cub.2003.10.003
PMID: 14588247
Abstract
Olfaction can elicit a rich perceptual experience. It is not known, however, whether olfactory information is decomposed into various components and processed in distinct perceptual centers as in other sensory systems, such as vision, where neural representations of different visual sensations are segregated in different cortical regions [1, 2], despite the fact that multiple structures of the primary olfactory cortex receive projections from the olfactory bulb [3]. Here, we use Drosophila as a model to investigate whether different olfactory information may be processed in separate brain structures. Organizations of the peripheral olfactory system are remarkably similar from mammals to insects [4]. As in vertebrates, the olfactory pathway in Drosophila follows similar convergence and divergence [5], and multiple high-order structures in the Drosophila brain, including the mushroom body (MB) and lateral horn (LH) of the protocerebrum, receive olfactory input [6, 7]. We specifically blocked neurotransmission in the MB while leaving the LH unaffected and examined its effect on olfactory avoidance and attraction behaviors. We show that blocking MB activity disrupted responses to attractive, but not repulsive, odors, and this finding suggests that attractive and repulsive olfactory information may be separately processed in higher olfactory centers of the Drosophila brain.
Details
- Title: Subtitle
- Blockade of Neurotransmission in Drosophila Mushroom Bodies Impairs Odor Attraction, but Not Repulsion
- Creators
- Yalin Wang - Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, NY 11724 USAAnn-Shyn Chiang - Department of Life Science, National Tsing Hua University, Hsinchu, 30043, Taiwan, R.O.CShouzhen Xia - Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, NY 11724 USAToshi Kitamoto - Department of Anesthesia, University of Iowa College of Medicine, Iowa City, IA 52242 USATim Tully - Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, NY 11724 USAYi Zhong - Cold Spring Harbor Laboratory, P.O. Box 100, Cold Spring Harbor, NY 11724 USA
- Resource Type
- Journal article
- Publication Details
- Current biology, Vol.13(21), pp.1900-1904
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.cub.2003.10.003
- PMID
- 14588247
- ISSN
- 0960-9822
- eISSN
- 1879-0445
- Language
- English
- Date published
- 10/28/2003
- Academic Unit
- Iowa Neuroscience Institute; Anesthesia; Neuroscience and Pharmacology
- Record Identifier
- 9984006314402771
Metrics
22 Record Views