Journal article
Blocking IL-10 enhances bacillus Calmette-Guérin induced T helper Type 1 immune responses and anti-bladder cancer immunity
Oncoimmunology, Vol.1(7), pp.1183-1185
10/01/2012
DOI: 10.4161/onci.20640
PMCID: PMC3494639
PMID: 23170273
Abstract
Proper induction of Th1 immunity is required for effective immunotherapy of bladder cancer with the bacillus Calmette-Guérin (BCG). Interleukin-10 (IL-10) downregulates the Th1 immune response and is associated with BCG therapy failure. We evaluated BCG plus IL-10 blocking antibodies and found that this combination therapy induces enhanced Th1 immune responses and anti-bladder cancer immunity in preclinical animal models.
Details
- Title: Subtitle
- Blocking IL-10 enhances bacillus Calmette-Guérin induced T helper Type 1 immune responses and anti-bladder cancer immunity
- Creators
- Yi Luo - Department of Urology
- Resource Type
- Journal article
- Publication Details
- Oncoimmunology, Vol.1(7), pp.1183-1185
- DOI
- 10.4161/onci.20640
- PMID
- 23170273
- PMCID
- PMC3494639
- NLM abbreviation
- Oncoimmunology
- ISSN
- 2162-4011
- eISSN
- 2162-402X
- Language
- English
- Date published
- 10/01/2012
- Academic Unit
- Urology
- Record Identifier
- 9984320068602771
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