Journal article
Blood Pressure as an Independent Prognostic Factor in Acute Ischemic Stroke
Canadian journal of neurological sciences, Vol.33(1), pp.34-38
02/2006
DOI: 10.1017/S0317167100004662
PMID: 16583719
Abstract
Background and purpose: Blood pressure is elevated in most patients during acute ischemic stroke, but the prognostic significance of this is unclear as the current data yield conflicting results.
Methods: Admission blood pressure from the 1281 patients in the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) was analyzed for prognostic significance as well as the risk of hemorrhagic transformation. We also examined weighted-average blood pressure over seven days, and the impact of a 30% change in blood pressure in 24 hours. Patients with severe hypertension were excluded from the TOAST trial.
Results: Increasing systolic blood pressure (SBP) on admission, but not diastolic (DBP) or mean arterial pressure (MAP) was predictive of poor outcome, but this effect was not significant after adjustment for other know prognostic factors. Increasing weighted-average SBP and MAP over seven days were predictive for poor outcome, but a 30% change in blood pressure over 24 hours was not.
Conclusions: Admission blood pressure is not an independent prognostic factor in acute ischemic stroke, but the weighted-average of SBP and MAP over seven days probably does have predictive value with higher values having a worse prognosis. A prospective trial of blood pressure control during acute stroke is needed.
Details
- Title: Subtitle
- Blood Pressure as an Independent Prognostic Factor in Acute Ischemic Stroke
- Creators
- Matt B Jensen - Stroke Center, University of California, San Diego, San Diego, CaliforniaBongin Yoo - Department of Biostatistics, University of Iowa College of Public Health, Iowa City, Iowa, USAWilliam R Clarke - Department of Biostatistics, University of Iowa College of Public Health, Iowa City, Iowa, USAPatricia H Davis - Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa, USAHarold P Adams - Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Canadian journal of neurological sciences, Vol.33(1), pp.34-38
- Publisher
- Cambridge University Press; Cambridge, UK
- DOI
- 10.1017/S0317167100004662
- PMID
- 16583719
- ISSN
- 0317-1671
- eISSN
- 2057-0155
- Language
- English
- Date published
- 02/2006
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020849002771
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