Blood Vessel Function and Cognition in Elderly Patients With Atherosclerosis

David J Moser; Karin F Hoth; Robert G Robinson; Jane S Paulsen; Christine A Sinkey; Michelle L Benjamin; Susan K Schultz; William G Haynes

doi:10.1161/01.STR.0000145050.35039.51

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Blood Vessel Function and Cognition in Elderly Patients With Atherosclerosis

Journal article

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Blood Vessel Function and Cognition in Elderly Patients With Atherosclerosis

David J Moser, Karin F Hoth, Robert G Robinson, Jane S Paulsen, Christine A Sinkey, Michelle L Benjamin, Susan K Schultz and William G Haynes

Stroke (1970), Vol.35(11), pp.e369-e372

11/2004

DOI: 10.1161/01.STR.0000145050.35039.51

PMID: 15472091

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Abstract

Background and purpose: Although a strong relationship has been established between vascular disease and cognitive decline, the current challenge is to identify vascular risk factors and mechanisms that are associated with cognitive function before the development of severe dysfunction (eg, vascular dementia). This study was conducted to determine the relationship between blood vessel function and cognition in elderly patients with atherosclerosis. Methods: Participants were 14 elderly individuals with atherosclerotic vascular disease, who had no history of stroke, cardiac surgery, or dementia diagnosis. Forearm blood flow was measured before and after brachial artery infusion of 3 vasoactive agents (verapamil, acetylcholine, nitroprusside), and these measures of vessel function were then correlated with neuropsychological performance (total scale score on the Repeatable Battery for the Assessment of Neuropsychological Status). Results: Positive correlations were found between neuropsychological performance and vasodilation in response to all 3 agents, with 2 reaching statistical significance (verapamil: rho=0.78, P=0.001; nitroprusside: rho=0.56, P=0.038) and the third showing a strong trend toward significance (acetylcholine: rho=0.49, P=0.076). Correlations between neuropsychological performance and more conventional vascular-related variables were much weaker. Conclusions: These data provide preliminary evidence of a relationship between resistance vessel function and neuropsychological performance. With further research, measures of vessel dysfunction may be useful in identifying individuals at risk for cognitive decline and vascular dementia.

Details

Title: Subtitle: Blood Vessel Function and Cognition in Elderly Patients With Atherosclerosis
Creators: David J Moser - From the Departments of Psychiatry (D.J.M., K.F.H., R.G.R., J.S.P., M.L.B., S.K.S.), Internal Medicine (C.A.S., W.G.H.), and the General Clinical Research Center (W.G.H.), University of Iowa Carver College of Medicine, Iowa City, Iowa
Karin F Hoth - From the Departments of Psychiatry (D.J.M., K.F.H., R.G.R., J.S.P., M.L.B., S.K.S.), Internal Medicine (C.A.S., W.G.H.), and the General Clinical Research Center (W.G.H.), University of Iowa Carver College of Medicine, Iowa City, Iowa
Robert G Robinson - From the Departments of Psychiatry (D.J.M., K.F.H., R.G.R., J.S.P., M.L.B., S.K.S.), Internal Medicine (C.A.S., W.G.H.), and the General Clinical Research Center (W.G.H.), University of Iowa Carver College of Medicine, Iowa City, Iowa
Jane S Paulsen - From the Departments of Psychiatry (D.J.M., K.F.H., R.G.R., J.S.P., M.L.B., S.K.S.), Internal Medicine (C.A.S., W.G.H.), and the General Clinical Research Center (W.G.H.), University of Iowa Carver College of Medicine, Iowa City, Iowa
Christine A Sinkey - From the Departments of Psychiatry (D.J.M., K.F.H., R.G.R., J.S.P., M.L.B., S.K.S.), Internal Medicine (C.A.S., W.G.H.), and the General Clinical Research Center (W.G.H.), University of Iowa Carver College of Medicine, Iowa City, Iowa
Michelle L Benjamin - From the Departments of Psychiatry (D.J.M., K.F.H., R.G.R., J.S.P., M.L.B., S.K.S.), Internal Medicine (C.A.S., W.G.H.), and the General Clinical Research Center (W.G.H.), University of Iowa Carver College of Medicine, Iowa City, Iowa
Susan K Schultz - From the Departments of Psychiatry (D.J.M., K.F.H., R.G.R., J.S.P., M.L.B., S.K.S.), Internal Medicine (C.A.S., W.G.H.), and the General Clinical Research Center (W.G.H.), University of Iowa Carver College of Medicine, Iowa City, Iowa
William G Haynes - From the Departments of Psychiatry (D.J.M., K.F.H., R.G.R., J.S.P., M.L.B., S.K.S.), Internal Medicine (C.A.S., W.G.H.), and the General Clinical Research Center (W.G.H.), University of Iowa Carver College of Medicine, Iowa City, Iowa
Resource Type: Journal article
Publication Details: Stroke (1970), Vol.35(11), pp.e369-e372
DOI: 10.1161/01.STR.0000145050.35039.51
PMID: 15472091
NLM abbreviation: Stroke
ISSN: 0039-2499
eISSN: 1524-4628
Language: English
Date published: 11/2004
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Medicine Administration; Internal Medicine
Record Identifier: 9984003472702771

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