Journal article
Blood culture time to positivity in febrile infants with bacteremia
JAMA pediatrics, Vol.168(9), pp.844-849
09/2014
DOI: 10.1001/jamapediatrics.2014.895
PMID: 25048522
Abstract
Blood cultures are often obtained as part of the evaluation of infants with fever and these infants are typically observed until their cultures are determined to have no growth. However, the time to positivity of blood culture results in this population is not known.
To determine the time to positivity of blood culture results in febrile infants admitted to a general inpatient unit.
Multicenter, retrospective, cross-sectional evaluation of blood culture time to positivity. Data were collected by community and academic hospital systems associated with the Pediatric Research in Inpatient Settings Network. The study included febrile infants 90 days of age or younger with bacteremia and without surgical histories outside of an intensive care unit.
Blood culture growing pathogenic bacteria.
Time to positivity and proportion of positive blood culture results that become positive more than 24 hours after placement in the analyzer.
A total of 392 pathogenic blood cultures were included from 17 hospital systems across the United States. The mean (SD) time to positivity was 15.41 (8.30) hours. By 24 hours, 91% (95% CI, 88-93) had turned positive. By 36 and 48 hours, 96% (95% CI, 95-98) and 99% (95% CI, 97-100) had become positive, respectively.
Most pathogens in febrile, bacteremic infants 90 days of age or younger hospitalized on a general inpatient unit will be identified within 24 hours of collection. These data suggest that inpatient observation of febrile infants for more than 24 hours may be unnecessary in most infants.
Details
- Title: Subtitle
- Blood culture time to positivity in febrile infants with bacteremia
- Creators
- Eric A Biondi - University of Rochester Medical Center, Rochester, New YorkMatthew Mischler - University of Illinois College of Medicine, PeoriaKaren E Jerardi - Cincinnati Children's Hospital Medical Center, Division of Hospital Medicine, Cincinnati, OhioAngela M Statile - Cincinnati Children's Hospital Medical Center, Division of Hospital Medicine, Cincinnati, OhioJason French - Children's Hospital Colorado, AuroraRianna Evans - The Children's Hospital of The King's Daughters, Norfolk, VirginiaVivian Lee - Children's Hospital Los Angeles, Los Angeles, CaliforniaClifford Chen - Children's Medical Center, University of Texas Southwestern, DallasCarl Asche - University of Illinois College of Medicine, Peoria8College of Pharmacy, University of Illinois at ChicagoJinma Ren - University of Illinois College of Medicine, PeoriaSamir S Shah - Cincinnati Children's Hospital Medical Center, Division of Hospital Medicine, Cincinnati, Ohio9Section Editor, JAMA PediatricsPediatric Research in Inpatient Settings (PRIS) Network
- Contributors
- Kelly E Wood (Contributor) - University of Iowa, Stead Family Department of Pediatrics
- Resource Type
- Journal article
- Publication Details
- JAMA pediatrics, Vol.168(9), pp.844-849
- DOI
- 10.1001/jamapediatrics.2014.895
- PMID
- 25048522
- NLM abbreviation
- JAMA Pediatr
- ISSN
- 2168-6203
- eISSN
- 2168-6211
- Language
- English
- Date published
- 09/2014
- Academic Unit
- Stead Family Department of Pediatrics; Hospital Medicine
- Record Identifier
- 9984093502602771
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