Journal article
Blood flow changes following 137Cs irradiation in a rat glioma model
Radiation research, Vol.115(3), pp.586-594
1988
DOI: 10.2307/3577307
PMID: 3174939
Abstract
Blood flow changes in response to 20 Gy 137Cs whole brain irradiation were measured with quantitative autoradiography of [14C]iodoantipyrine (IAP) in intracerebral grafts of the 36B-10 rat glioma, the brain around tumor (BAT), the contralateral corpus callosum, and the contralateral cerebral cortex. Irradiations were delivered on Day 14 post-transplantation, and measurements of flow (F) were performed with IAP on Day 15 or Day 16. Mean values of F were determined in individual tumors and in treatment groups. In 15- and 16-day-old unirradiated control tumors, the group mean F was 0.31 ml.g-1.min-1. In both 15- and 16-day-old tumor groups irradiated on Day 14 (Day 1 and 2 postirradiation tumors) the mean F for each day's group was 0.52 ml.g-1.min-1, 68% higher than the control (P less than 0.01). Flow in the BAT and the contralateral corpus callosum similarly was increased at these times (P less than 0.01). Flow in the contralateral cerebral cortex was 1.1, 1.5, and 1.3 ml.g-1.min-1 in the control, 1 day postirradiated, and 2 day postirradiated groups, respectively, but these increases were not significantly different from the control. These data indicate that flow increases in the intracerebral gliomas as well as in normal brain regions during the 2 days following 20 Gy irradiation. Changes such as these following radiotherapy may have important effects on the bioavailability of chemotherapeutic drugs.
Details
- Title: Subtitle
- Blood flow changes following 137Cs irradiation in a rat glioma model
- Creators
- A. M SPENCE - Univ. Washington school medicine, div. neurology, Seattle WA 98195, United StatesM. M GRAHAM - Univ. Washington school medicine, div. neurology, Seattle WA 98195, United StatesG. L ABBOTT - Univ. Washington school medicine, div. neurology, Seattle WA 98195, United StatesM MUZI - Univ. Washington school medicine, div. neurology, Seattle WA 98195, United StatesT. K LEWELLEN - Univ. Washington school medicine, div. neurology, Seattle WA 98195, United States
- Resource Type
- Journal article
- Publication Details
- Radiation research, Vol.115(3), pp.586-594
- Publisher
- Radiation Research Society; Oak Brook, Il
- DOI
- 10.2307/3577307
- PMID
- 3174939
- ISSN
- 0033-7587
- eISSN
- 1938-5404
- Language
- English
- Date published
- 1988
- Academic Unit
- Radiology; Radiation Oncology
- Record Identifier
- 9984047700702771
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