Blood flow through vasa vasorum of coronary arteries in atherosclerotic monkeys

D D Heistad; M L Armstrong

doi:10.1161/01.atv.6.3.326

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Blood flow through vasa vasorum of coronary arteries in atherosclerotic monkeys

Journal article

Open access

Blood flow through vasa vasorum of coronary arteries in atherosclerotic monkeys

D D Heistad and M L Armstrong

Arteriosclerosis (Dallas, Tex.), Vol.6(3), pp.326-331

05/1986

DOI: 10.1161/01.atv.6.3.326

PMID: 3707431

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Abstract

Morphologic studies and postmortem arteriograms provide qualitative evidence that atherosclerosis induces neovascularization in coronary arteries. In this study we obtained the first measurements of blood flow through vasa vasorum in atherosclerotic coronary arteries. We measured blood flow with microspheres to intima media and to adventitia in normal and atherosclerotic cynomolgus monkeys. Blood flow to adventitia was not altered by atherosclerosis. The blood flow to intima media, however, was increased more than fivefold by atherosclerosis: flow was 3 +/- 1 in normal animals and 16 +/- 5 in atherosclerotic monkeys (p less than 0.05). Blood flow was threefold greater in atherosclerotic than in normal coronary arteries during adenosine-induced vasodilatation, which suggests that proliferation of new vessels, not dilatation of existing vessels, accounts for the increase in flow through vasa in intima media. Histologic studies indicated that vasa vasorum to intima media in atherosclerotic coronary arteries originate from adventitial vasa. We conclude that: 1) there is a large increase in blood flow through vasa vasorum to intima media, but not to adventitia, in atherosclerotic coronary arteries; and 2) increased flow is produced primarily by proliferation of new vessels that originate from adventitial vasa.

Coronary Circulation

Diet, Atherogenic

Coronary Vessels - pathology

Animals

Coronary Vessels - physiopathology

Arteriosclerosis - physiopathology

Macaca fascicularis

Male

Arteriosclerosis - pathology

Details

Title: Subtitle: Blood flow through vasa vasorum of coronary arteries in atherosclerotic monkeys
Creators: D D Heistad
M L Armstrong
Resource Type: Journal article
Publication Details: Arteriosclerosis (Dallas, Tex.), Vol.6(3), pp.326-331
DOI: 10.1161/01.atv.6.3.326
PMID: 3707431
NLM abbreviation: Arteriosclerosis
ISSN: 0276-5047
eISSN: 2330-9180
Publisher: United States
Grant note: HL16066 / NHLBI NIH HHS HL14230 / NHLBI NIH HHS HL14388 / NHLBI NIH HHS
Language: English
Date published: 05/1986
Academic Unit: Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
Record Identifier: 9984040221902771

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