Journal article
Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies
Nature communications, Vol.12(1), pp.2329-9
04/22/2021
DOI: 10.1038/s41467-021-22370-2
PMCID: PMC8062567
PMID: 33888689
Abstract
The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations between blood omega-3 fatty acid levels and risk for all-cause mortality. Over a median of 16 years of follow-up, 15,720 deaths occurred among 42,466 individuals. We found that, after multivariable adjustment for relevant risk factors, risk for death from all causes was significantly lower (by 15-18%, at least p < 0.003) in the highest vs the lowest quintile for circulating long chain (20-22 carbon) omega-3 fatty acids (eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids). Similar relationships were seen for death from cardiovascular disease, cancer and other causes. No associations were seen with the 18-carbon omega-3, alpha-linolenic acid. These findings suggest that higher circulating levels of marine n-3 PUFA are associated with a lower risk of premature death.
Details
- Title: Subtitle
- Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies
- Creators
- William S Harris - The Fatty Acid Research Institute, Sioux Falls, SD, USA. wsh@faresinst.comNathan L Tintle - Department of Mathematics and Statistics, Dordt University, Sioux Center, IA, USAFumiaki Imamura - MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UKFrank Qian - Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USAAndres V Ardisson Korat - Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USAMatti Marklund - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USALuc Djoussé - Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USAJulie K Bassett - Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, AustraliaPierre-Hugues Carmichael - Centre D'excellence Sur le Vieillissement de Québec, CIUSSS-CN, Quebec, QC, CanadaYun-Yu Chen - Department of Medicine, Taipei Veterans General Hospital; and Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, TaiwanYoichiro Hirakawa - Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanLeanne K Küpers - Division of Human Nutrition and Health, Wageningen University, Wageningen, The NetherlandsFederica Laguzzi - Institute of Environmental Medicine, Karolinska Institute, Stockholm, SwedenMaria Lankinen - Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, FinlandRachel A Murphy - Cancer Control Research, BC Cancer Agency; and School of Population and Public Health, University of British Columbia, Vancouver, BC, CanadaCécilia Samieri - Bordeaux Population Health Research Centre, INSERM, University of Bordeaux, Bordeaux, FranceMackenzie K Senn - USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USAPeilin Shi - Freidman School of Nutrition Science and Policy, Tufts University, Boston, MA, USAJyrki K Virtanen - Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, FinlandIngeborg A Brouwer - Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam and Amsterdam Public Health Research Institute, Amsterdam, The NetherlandsKuo-Liong Chien - Department of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanGudny Eiriksdottir - Icelandic Heart Association, Kopavogur, IcelandNita G Forouhi - MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UKJohanna M Geleijnse - Division of Human Nutrition and Health, Wageningen University, Wageningen, The NetherlandsGraham G Giles - Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, AustraliaVilmundur Gudnason - School of Health Sciences, University of Iceland, Reykjavík, IcelandCatherine Helmer - Bordeaux Population Health Research Centre, INSERM, University of Bordeaux, Bordeaux, FranceAllison Hodge - Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, AustraliaRebecca Jackson - Department of Internal Medicine, Division of Endocrinology, The Ohio State University, Columbus, OH, USAKay-Tee Khaw - MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UKMarkku Laakso - Institute of Clinical Medicine, University of Eastern Finland, Kuopio, FinlandHeidi Lai - Department of Primary Care and Public Health, Imperial College, London, UKDanielle Laurin - VITAM Research Centers, Laval University, Quebec, QC, CanadaKarin Leander - Institute of Environmental Medicine, Karolinska Institute, Stockholm, SwedenJoan Lindsay - School of Epidemiology and Public Health, University of Ottawa, Ottawa, CanadaRenata Micha - Freidman School of Nutrition Science and Policy, Tufts University, Boston, MA, USAJaako Mursu - Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, FinlandToshiharu Ninomiya - Department of Epidemiology and Public Health, Kyushu University, Fukuoka, JapanWendy Post - Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, AustraliaBruce M Psaty - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USAUlf Risérus - Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, SwedenJennifer G Robinson - Department of Epidemiology, University of Iowa, Iowa City, IA, USAAladdin H Shadyab - Department of Family Medicine and Public Health, University of California San Diego School of Medicine, La Jolla, CA, USALinda Snetselaar - Department of Epidemiology, University of Iowa, Iowa City, IA, USAAleix Sala-Vila - Hospital del Mar Medical Research Institute & Barcelona βeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, SpainYangbo Sun - Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USALyn M Steffen - School of Public Health, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USAMichael Y Tsai - Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USANicholas J Wareham - MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UKAlexis C Wood - USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USAJason H Y Wu - The George Institute for Global Health and the Faculty of Medicine, University New South Wales, Sydney, AustraliaFrank Hu - Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USAQi Sun - Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USADavid S Siscovick - The New York Academy of Medicine, New York, NY, USARozenn N Lemaitre - Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USADariush Mozaffarian - Freidman School of Nutrition Science and Policy, Tufts University, Boston, MA, USAFatty Acids and Outcomes Research Consortium (FORCE)
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.12(1), pp.2329-9
- DOI
- 10.1038/s41467-021-22370-2
- PMID
- 33888689
- PMCID
- PMC8062567
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Language
- English
- Date published
- 04/22/2021
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984215049002771
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