Blood oxygen level-dependent and perfusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneys

Elizabeth A Sadowski; Arjang Djamali; Andrew L Wentland; Rebecca Muehrer; Bryan N Becker; Thomas M Grist; Sean B Fain

doi:10.1016/j.mri.2009.05.044

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Blood oxygen level-dependent and perfusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneys

Journal article

Peer reviewed

Blood oxygen level-dependent and perfusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneys

Elizabeth A Sadowski, Arjang Djamali, Andrew L Wentland, Rebecca Muehrer, Bryan N Becker, Thomas M Grist and Sean B Fain

Magnetic resonance imaging, Vol.28(1), pp.56-64

01/2010

DOI: 10.1016/j.mri.2009.05.044

PMCID: PMC2891158

PMID: 19577402

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https://www.ncbi.nlm.nih.gov/pmc/articles/2891158View

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Abstract

Functional magnetic resonance imaging (fMRI) is a powerful tool for examining kidney function, including organ blood flow and oxygen bioavailability. We have used contrast enhanced perfusion and blood oxygen level-dependent (BOLD) MRI to assess kidney transplants with normal function, acute tubular necrosis (ATN) and acute rejection. BOLD and MR-perfusion imaging were performed on 17 subjects with recently transplanted kidneys. There was a significant difference between medullary R2⁎ values in the group with acute rejection (R2⁎=16.2/s) compared to allografts with ATN (R2⁎=19.8/s; P=.047) and normal-functioning allografts (R2⁎=24.3/s;P=.0003). There was a significant difference between medullary perfusion measurements in the group with acute rejection (124.4±41.1 ml/100 g per minute) compared to those in patients with ATN (246.9±123.5 ml/100 g per minute; P=.02) and normal-functioning allografts (220.8±95.8 ml/100 g per minute; P=.02). This study highlights the utility of combining perfusion and BOLD MRI to assess renal function. We have demonstrated a decrease in medullary R2⁎ (decrease deoxyhemoglobin) on BOLD MRI and a decrease in medullary blood flow by MR perfusion imaging in those allografts with acute rejection, which indicates an increase in medullary oxygen bioavailability in allografts with rejection, despite a decrease in blood flow.

Blood flow

BOLD

Oxygen bioavailability

Perfusion MRI

Transplanted kidneys

Details

Title: Subtitle: Blood oxygen level-dependent and perfusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneys
Creators: Elizabeth A Sadowski - University of Wisconsin–Madison
Arjang Djamali - University of Wisconsin–Madison
Andrew L Wentland - University of Wisconsin–Madison
Rebecca Muehrer - University of Wisconsin–Madison
Bryan N Becker - University of Wisconsin–Madison
Thomas M Grist - University of Wisconsin–Madison
Sean B Fain - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Magnetic resonance imaging, Vol.28(1), pp.56-64
DOI: 10.1016/j.mri.2009.05.044
PMID: 19577402
PMCID: PMC2891158
NLM abbreviation: Magn Reson Imaging
ISSN: 0730-725X
eISSN: 1873-5894
Publisher: Elsevier Inc
Language: English
Date published: 01/2010
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
Record Identifier: 9984275058902771

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