Blood oxygenation changes resulting from trains of low frequency transcranial magnetic stimulation

Richard H. Thomson; Jerome J. Maller; Zafiris J. Daskalakis; Paul B. Fitzgerald

doi:10.1016/j.cortex.2011.04.028

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Blood oxygenation changes resulting from trains of low frequency transcranial magnetic stimulation

Journal article

Peer reviewed

Blood oxygenation changes resulting from trains of low frequency transcranial magnetic stimulation

Richard H. Thomson, Jerome J. Maller, Zafiris J. Daskalakis and Paul B. Fitzgerald

Cortex, Vol.48(4), pp.487-491

04/01/2012

DOI: 10.1016/j.cortex.2011.04.028

PMID: 21621761

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Abstract

The evoked responses to transcranial magnetic stimulation (TMS) have been previously demonstrated to be on average greater at the beginning of a session; however the physiological reason for this remains uncertain. In order to investigate a possible hemodynamic mechanism for this phenomenon, changes in oxy-hemoglobin (HbO) following trains of single pulse TMS was investigated using near infra-red spectroscopy (NIRS). TMS was delivered in trains of two and four pulses to left pre-frontal cortex (PFC) at a typical intensity and frequency (.2 Hz) used in neuroscience research. Both trains resulted in significant drops of HbO that remained after the cessation of TMS. The changes observed imply that arterial supply drops following suprathreshold TMS and oxygen consumption outstrips supply, resulting in a net drop of HbO. This study provides evidence that at typical TMS delivery frequencies, local HbO levels remain at a sustained lower level than at the beginning of the session, potentially explaining changes in sensitivity to stimulation with repeated TMS pulses. (C) 2011 Elsevier Srl. All rights reserved.

Behavioral Sciences

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Details

Title: Subtitle: Blood oxygenation changes resulting from trains of low frequency transcranial magnetic stimulation
Creators: Richard H. Thomson - Monash Alfred Psychiatry Research centre
Jerome J. Maller - Monash Alfred Psychiatry Research centre
Zafiris J. Daskalakis - University of Toronto
Paul B. Fitzgerald - The Alfred Hospital
Resource Type: Journal article
Publication Details: Cortex, Vol.48(4), pp.487-491
DOI: 10.1016/j.cortex.2011.04.028
PMID: 21621761
NLM abbreviation: Cortex
ISSN: 0010-9452
eISSN: 1973-8102
Publisher: Elsevier
Number of pages: 5
Grant note: Constance and Stephen Lieber through a National Alliance for Research on Schizophrenia and Depression (NARSAD); NARSAD National Health and Medical Research Council (NHMRC); National Health & Medical Research Council (NHMRC) of Australia 178/05 / Australian Research Council (ARC); Australian Research Council Neuronetics Ltd.
Language: English
Date published: 04/01/2012
Academic Unit: Radiology
Record Identifier: 9984848508702771

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