Journal article
Blood pressure in human large cerebral arteries: A feasibility study
Journal of applied physiology (1985), Vol.138(3), pp.693-698
03/01/2025
DOI: 10.1152/japplphysiol.00825.2024
PMID: 39918464
Abstract
The lack of direct measures of brain blood pressure (BBP) has severely restricted understanding of cerebral pressure-flow relationships and their control. We sought to evaluate the feasibility of directly measuring BBP and its pulsatility between the aorta and middle cerebral artery (MCA) during elective endovascular surgical procedures.
We report five case studies (four female, 61 ± 13 years; Mean ± SD) of patients undergoing cerebrovascular interventional procedures for aneurysm and stenoses using direct BBP measures with the COMET 2 pressure guidewire system (Boston Scientific). Patients were supine, intubated and under anesthesia. The sensor wire was inserted via the femoral artery, measuring, as feasible, BP in aorta to-MCA vascular segments, referenced to the radial artery BP waveform (arterial catheter).
Mean arterial pressure varied between the radial (80 ± 18 mmHg), internal carotid artery (ICA; 70 ± 25 mmHg) and MCA (62 ± 29 mmHg) and marked interindividual heterogeneity was observed. Pulse pressure was higher in the radial artery (68 ± 23 mmHg) compared to the intracranial ICA (ICAi; 43 ± 29 mmHg) and MCA (M1; 25 ± 12 mmHg) segments.
Direct measures of BBP in humans are feasible in this interventional surgery model. Although limited by the small sample size, the results suggest a heterogenous pattern of change between systemic and brain measures of blood pressure and pulse pressure.
Details
- Title: Subtitle
- Blood pressure in human large cerebral arteries: A feasibility study
- Creators
- Leena N Shoemaker - Western UniversityTyson Matern - University of Iowa Hospitals and ClinicsFarah Kamar - Western UniversityKeith St Lawrence - University of LondonSantiago Ortega-Gutierrez - University of Iowa Hospitals and ClinicsMario Zanaty - University of IowaJ Kevin Shoemaker - Western University
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.138(3), pp.693-698
- DOI
- 10.1152/japplphysiol.00825.2024
- PMID
- 39918464
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 1522-1601
- eISSN
- 1522-1601
- Publisher
- AMER PHYSIOLOGICAL SOC
- Grant note
- Heart and Stroke Foundation of Canada (HSF) R01NS127114-01 / HHS | National Institutes of Health (NIH) R03NS126804 / HHS | National Institutes of Health (NIH) RO1NS138765 / HHS | National Institutes of Health (NIH) RGPIN-2024-06520 / Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC)
- Language
- English
- Electronic publication date
- 02/07/2025
- Date published
- 03/01/2025
- Academic Unit
- Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
- Record Identifier
- 9984786309502771
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