Blood pressure variability and white matter hyperintensities in older adults with cardiovascular disease

JOHN GUNSTAD; RONALD A COHEN; DAVID F TATE; ROBERT H PAUL; ATHENA POPPAS; KARIN HOTH; KRISTIN L MACGREGOR; ANGELA L JEFFERSON

doi:10.1080/08037050500364117

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Blood pressure variability and white matter hyperintensities in older adults with cardiovascular disease

Journal article

Open access

Peer reviewed

Blood pressure variability and white matter hyperintensities in older adults with cardiovascular disease

JOHN GUNSTAD, RONALD A COHEN, DAVID F TATE, ROBERT H PAUL, ATHENA POPPAS, KARIN HOTH, KRISTIN L MACGREGOR and ANGELA L JEFFERSON

Blood pressure, Vol.14(6), pp.353-358

2005

DOI: 10.1080/08037050500364117

PMCID: PMC3215278

PMID: 16403689

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Abstract

The present study examined the relationship between multiple blood pressure (BP) indices and white matter hyperintensities (WMH) in a sample of 39 older adults with cardiovascular disease (CVD). Resting BP was measured using an automated monitor every 10 min for 2 h. WMH were quantified on FLAIR images and separate indices were generated for neocortical, periventricular and subcortical brain regions. Correlation analyses revealed systolic BP variability was related to neocortical and total WMH. A function of systolic BP variability and average diastolic pressure showed the strongest relationships, including significant correlation to neocortical, subcortical and total WMH. No BP index was related to WMH in periventricular regions. Exploratory analyses showed only the function of systolic BP variability and average diastolic pressure predicted total WMH, whereas as age, CVD conditions and psychosocial factors did not. These findings demonstrate BP variability is an important contributor to WMH in older adults with CVD and suggests it may have differential relationships to WMH in different brain regions. Additional studies are needed to examine the role of autoregulatory systems in the development of WMH, particularly those using beat-to-beat measures of BP.

cardiovascular disease

Blood pressure

cerebrovascular disease

Details

Title: Subtitle: Blood pressure variability and white matter hyperintensities in older adults with cardiovascular disease
Creators: JOHN GUNSTAD - Kent State University, Kent, Ohio, USA
RONALD A COHEN - Brown Medical School, Providence, Rhode Island, USA
DAVID F TATE - Brown Medical School, Providence, Rhode Island, USA
ROBERT H PAUL - Brown Medical School, Providence, Rhode Island, USA
ATHENA POPPAS - Brown Medical School, Providence, Rhode Island, USA
KARIN HOTH - Brown Medical School, Providence, Rhode Island, USA
KRISTIN L MACGREGOR - Brown Medical School, Providence, Rhode Island, USA
ANGELA L JEFFERSON - Boston University, Boston, Massachusetts, USA
Resource Type: Journal article
Publication Details: Blood pressure, Vol.14(6), pp.353-358
DOI: 10.1080/08037050500364117
PMID: 16403689
PMCID: PMC3215278
NLM abbreviation: Blood Press
ISSN: 0803-7051
eISSN: 1651-1999
Grant note: P30 AG013846-10 || AG / National Institute on Aging : NIA\nF32 AG022773-02 || AG / National Institute on Aging : NIA
Language: English
Date published: 2005
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984066383202771

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