Journal article
Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis
Cancer causes & control, Vol.30(8), pp.889-900
08/2019
DOI: 10.1007/s10552-019-01188-w
PMCID: PMC6613988
PMID: 31165419
Abstract
To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL).
We used harmonized data from 13 case-control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables.
Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with NHL risk for men (OR 0.74; 95% CI 0.65-0.83) but not women (OR 0.92; 95% CI 0.83-1.03), p
= 0.014. Transfusion history was not associated with risk in other racial/ethnic groups. There was no trend with the number of transfusions, time since first transfusion, age at first transfusion, or decade of first transfusion, and further adjustment for socioeconomic status, body mass index, smoking, alcohol use, and HCV seropositivity did not alter the results. Associations for NHW men were stronger in hospital-based (OR 0.56; 95% CI 0.45-0.70) but still apparent in population-based (OR 0.84; 95% CI 0.72-0.98) studies.
In the setting of a literature reporting mainly null and some positive associations, and the lack of a clear methodologic explanation for our inverse association restricted to NHW men, the current body of evidence suggests that there is no association of blood transfusion with risk of NHL.
Details
- Title: Subtitle
- Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis
- Creators
- James R Cerhan - Mayo Clinic Rochester, MNEleanor Kane - University of YorkClaire M Vajdic - UNSW SydneyMartha S Linet - National Institutes of HealthAlain Monnereau - Sorbonne Paris CitéLeslie Bernstein - City Of Hope National Medical CenterSilvia de Sanjose - Centro de Investigación Biomédica en Red de CáncerBrian C-H Chiu - University of ChicagoJohn J Spinelli - University of British ColumbiaL Dal Maso - Centro di Riferimento OncologicoYawei Zhang - Yale UniversityBeth R Larrabee - Mayo Clinic in FloridaWendy Cozen - University of Southern CaliforniaAlexandra G Smith - University of YorkJacqueline Clavel - Sorbonne Paris CitéDiego Serraino - Centro di Riferimento OncologicoTongzhang Zheng - Brown UniversityElizabeth A Holly - University of California, San FranciscoDennis D Weisenberger - City Of Hope National Medical CenterSusan L Slager - Mayo Clinic Rochester, MNPaige M Bracci - University of California, San Francisco
- Resource Type
- Journal article
- Publication Details
- Cancer causes & control, Vol.30(8), pp.889-900
- DOI
- 10.1007/s10552-019-01188-w
- PMID
- 31165419
- PMCID
- PMC6613988
- NLM abbreviation
- Cancer Causes Control
- ISSN
- 0957-5243
- eISSN
- 1573-7225
- Grant note
- R01 CA092153 / NCI NIH HHS N01 PC067010 / NCI NIH HHS R01 CA045614 / NCI NIH HHS R01 CA062006 / NCI NIH HHS N01 PC067008 / NCI NIH HHS R01 AI050850 / NIAID NIH HHS N01 PC065064 / NCI NIH HHS P50 CA097274 / NCI NIH HHS R01 CA087014 / NCI NIH HHS R01 CA100555 / NCI NIH HHS N01CO12400 / NCI NIH HHS R03 CA089745 / NCI NIH HHS R21 CA165923 / NCI NIH HHS UL1 TR001863 / NCATS NIH HHS N01 PC067009 / NCI NIH HHS
- Language
- English
- Date published
- 08/2019
- Academic Unit
- Epidemiology
- Record Identifier
- 9984368098102771
Metrics
22 Record Views