Journal article
Bloodstream Infections in Very Low Birth Weight Infants with Intestinal Failure
The Journal of pediatrics, Vol.160(1), pp.54-59.e2
01/2012
DOI: 10.1016/j.jpeds.2011.06.034
PMCID: PMC3419271
PMID: 21840538
Abstract
To examine pathogens and other characteristics associated with late-onset bloodstream infections (BSIs) in infants with intestinal failure (IF) as a consequence of necrotizing enterocolitis (NEC).
Infants weighing 401-1500 g at birth who survived for >72 hours and received care at Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network centers were studied. The frequency of culture-positive BSI and pathogens were compared in infants with medically managed NEC, NEC managed surgically without IF, and surgical IF. Among infants with IF, the duration of parenteral nutrition (PN) and other outcomes were evaluated.
A total of 932 infants were studied (IF, n = 78; surgical NEC without IF, n = 452; medical NEC, n = 402). The proportion with BSI after diagnosis of NEC was higher in the infants with IF than in those with surgical NEC (P = .007) or medical NEC (P < .001). Gram-positive pathogens were most frequent. Among infants with IF, an increased number of infections was associated with longer hospitalization and duration of PN (median stay: 172 for those with 0 infections, 188 days for those with 1 infection, and 260 days for those with ≥2 infections [P = .06]; median duration of PN: 90, 112, and 115 days, respectively [P = .003]) and decreased achievement of full feeds during hospitalization (87%, 67%, and 50%, respectively; P = .03).
Recurrent BSIs are common in very low birth weight infants with IF. Gram-positive bacteria were the most commonly identified organisms in these infants.
Details
- Title: Subtitle
- Bloodstream Infections in Very Low Birth Weight Infants with Intestinal Failure
- Creators
- Edward F Bell - Department of Pediatrics, University of Iowa, Iowa City, IAConrad R Cole - Intestinal Rehabilitation Program, Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children’s Hospital Medical Center, Cincinnati, OHNellie I Hansen - Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NCRosemary D Higgins - Eunice Kennedy Shiver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MDSeetha Shankaran - Department of Pediatrics, Wayne State, Detroit, MIAbbot R Laptook - Department of Pediatrics, Brown University, Providence, RIMichele C Walsh - Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OHEllen C Hale - Department of Pediatrics, Emory University School of Medicine, Atlanta, GANancy S Newman - Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OHAbhik Das - Statistics and Epidemiology Unit, RTI International, Rockville, MDBarbara J Stoll - Department of Pediatrics, Emory University School of Medicine, Atlanta, GANational Institute of Child Health and Human Development’s Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.160(1), pp.54-59.e2
- DOI
- 10.1016/j.jpeds.2011.06.034
- PMID
- 21840538
- PMCID
- PMC3419271
- NLM abbreviation
- J Pediatr
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Publisher
- Elsevier Inc
- Grant note
- National Institutes of Health and the Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Language
- English
- Date published
- 01/2012
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984093474002771
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