Blue light flexible cystoscopy with hexaminolevulinate in non-muscle-invasive bladder cancer: review of the clinical evidence and consensus statement on optimal use in the USA - update 2018

Yair Lotan; Trinity J. Bivalacqua; Tracy Downs; William Huang; Jeffrey Jones; Ashish M. Kamat; Badrinath Konety; Per-Uno Malmstrom; James McKiernan; Michael O'Donnell; Sanjay Patel; Kamal Pohar; Matthew Resnick; Alexander Sankin; Angela Smith; Gary Steinberg; Edouard Trabulsi; Michael Woods; Siamak Daneshmand

doi:10.1038/s41585-019-0184-4

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Blue light flexible cystoscopy with hexaminolevulinate in non-muscle-invasive bladder cancer: review of the clinical evidence and consensus statement on optimal use in the USA - update 2018

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Blue light flexible cystoscopy with hexaminolevulinate in non-muscle-invasive bladder cancer: review of the clinical evidence and consensus statement on optimal use in the USA - update 2018

Yair Lotan, Trinity J. Bivalacqua, Tracy Downs, William Huang, Jeffrey Jones, Ashish M. Kamat, Badrinath Konety, Per-Uno Malmstrom, James McKiernan, Michael O'Donnell, …

Nature reviews. Urology, Vol.16(6), pp.377-386

06/01/2019

DOI: 10.1038/s41585-019-0184-4

PMCID: PMC7136177

PMID: 31019310

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Abstract

Blue light cystoscopy (BLC) with hexaminolevulinate (HAL) during transurethral resection of bladder cancer improves detection of non-muscle-invasive bladder cancer (NMIBC) and reduces recurrence rates. Flexible BLC was approved by the FDA in 2018 for use in the surveillance setting and was demonstrated to improve detection. Results of a phase III prospective multicentre study of blue light flexible cystoscopy (BLFC) in surveillance of intermediate-risk and high-risk NMIBC showed that 20.6% of malignancies were identified only by BLFC. Improved detection rates in the surveillance setting are anticipated to lead to improved clinical outcomes by reducing future recurrences and earlier identification of tumours that are unresponsive to therapy. Thus, BLFC has a role in surveillance cystoscopy, and determining which patients will benefit from BLFC and optimal and cost-effective ways of incorporating this technology into surveillance cystoscopy must be developed.

Life Sciences & Biomedicine

Science & Technology

Urology & Nephrology

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Title: Subtitle: Blue light flexible cystoscopy with hexaminolevulinate in non-muscle-invasive bladder cancer: review of the clinical evidence and consensus statement on optimal use in the USA - update 2018
Creators: Yair Lotan - The University of Texas Southwestern Medical Center
Trinity J. Bivalacqua - Johns Hopkins University
Tracy Downs - University of Wisconsin–Madison
William Huang - New York University
Jeffrey Jones - Michael E. DeBakey VA Medical Center
Ashish M. Kamat - The University of Texas MD Anderson Cancer Center
Badrinath Konety - University of Minnesota
Per-Uno Malmstrom - Uppsala University
James McKiernan - Columbia University
Michael O'Donnell - Univ Iowa, Dept Urol, Iowa City, IA 52242 USA
Sanjay Patel - University of Oklahoma
Kamal Pohar - The Ohio State University
Matthew Resnick - Vanderbilt University
Alexander Sankin - Yeshiva University
Angela Smith - University of North Carolina at Chapel Hill
Gary Steinberg - University of Chicago
Edouard Trabulsi - Thomas Jefferson University
Michael Woods - Loyola University Chicago
Siamak Daneshmand - University of Southern California
Resource Type: Journal article
Publication Details: Nature reviews. Urology, Vol.16(6), pp.377-386
DOI: 10.1038/s41585-019-0184-4
PMID: 31019310
PMCID: PMC7136177
NLM abbreviation: Nat Rev Urol
ISSN: 1759-4812
eISSN: 1759-4820
Publisher: NATURE PORTFOLIO
Number of pages: 10
Grant note: P30CA086862 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
Language: English
Date published: 06/01/2019
Academic Unit: Urology
Record Identifier: 9984320076802771

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