Journal article
Body fat indices and biomarkers of inflammation: a cross-sectional study with implications for obesity and peri-implant oral health
The International journal of oral and maxillofacial implants, Vol.29(6), pp.1429-1434
11/2014
DOI: 10.11607/jomi.3758
PMID: 25397806
Abstract
To examine the relationships between three measures of body fat-body mass index (BMI), waist circumference (WC), and total body fat percent-and markers of inflammation around dental implants in stable periodontal maintenance patients.
Seventy-three subjects were enrolled in this cross-sectional assessment. The study visit consisted of a physical examination that included anthropologic measurements of body composition (BMI, WC, body fat %); intraoral assessments were performed (full-mouth plaque index, periodontal and peri-implant comprehensive examinations) and peri-implant sulcular fluid (PISF) was collected on the study implants. Levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, IL-12, IL-17, tumor necrosis factor-α, C-reactive protein, osteoprotegerin, leptin, and adiponectin in the PISF were measured using multiplex proteomic immunoassays. Correlation analysis with body fat measures was then performed using appropriate statistical methods.
After adjustments for covariates, regression analyses revealed statistically significant correlation between IL-1β in PISF and WC (R = 0.33; P = .0047).
In this study in stable periodontal maintenance patients, a modest but statistically significant positive correlation was observed between the levels of IL-1β, a major proinflammatory cytokine in PISF, and WC, a reliable measure of central obesity.
Details
- Title: Subtitle
- Body fat indices and biomarkers of inflammation: a cross-sectional study with implications for obesity and peri-implant oral health
- Creators
- Satheesh ElangovanKim A BrogdenDeborah V DawsonDerek BlanchetteKeyla Pagan-RiveraClark M StanfordGeorgia K JohnsonErica ReckerRob BowersWilliam G HaynesGustavo Avila-Ortiz
- Resource Type
- Journal article
- Publication Details
- The International journal of oral and maxillofacial implants, Vol.29(6), pp.1429-1434
- DOI
- 10.11607/jomi.3758
- PMID
- 25397806
- NLM abbreviation
- Int J Oral Maxillofac Implants
- ISSN
- 0882-2786
- eISSN
- 1942-4434
- Publisher
- United States
- Grant note
- 2UL1 TR000442-06 / NCATS NIH HHS R01 DE014390 / NIDCR NIH HHS
- Language
- English
- Date published
- 11/2014
- Academic Unit
- Preventive and Community Dentistry; Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Prosthodontics; Orthopedics and Rehabilitation; Pediatric Dentistry; Craniofacial Anomalies Research Center; Family Dentistry; Periodontics
- Record Identifier
- 9984065989702771
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