Body fatness during childhood and adolescence and breast density in young women: a prospective analysis

Kimberly A Bertrand; Heather J Baer; E John Orav; Catherine Klifa; John A Shepherd; Linda Van Horn; Linda Snetselaar; Victor J Stevens; Nola M Hylton; Joanne F Dorgan

doi:10.1186/s13058-015-0601-4

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Body fatness during childhood and adolescence and breast density in young women: a prospective analysis

Journal article

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Body fatness during childhood and adolescence and breast density in young women: a prospective analysis

Kimberly A Bertrand, Heather J Baer, E John Orav, Catherine Klifa, John A Shepherd, Linda Van Horn, Linda Snetselaar, Victor J Stevens, Nola M Hylton and Joanne F Dorgan

Breast cancer research : BCR, Vol.17(1), pp.95-95

07/16/2015

DOI: 10.1186/s13058-015-0601-4

PMCID: PMC4502611

PMID: 26174168

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Abstract

Overweight and obesity in childhood and adolescence are associated with reduced breast cancer risk, independent of adult body mass index (BMI). These associations may be mediated through breast density. We prospectively examined associations of early life body fatness with adult breast density measured by MRI in 182 women in the Dietary Intervention Study in Children (DISC) who were ages 25-29 at follow-up. Height, weight, and other factors were measured at baseline (ages 8-10) and annual clinic visits through adolescence. We used linear mixed-effects models to quantify associations of percent breast density and dense and non-dense breast volume at ages 25-29 with quartiles of age-specific youth body mass index (BMI) Z-scores, adjusting for clinic, treatment group, current adult BMI, and other well-established risk factors for breast cancer and predictors of breast density. We observed inverse associations between age-specific BMI Z-scores at all youth clinic visits and percent breast density, adjusting for current adult BMI and other covariates (all p values <0.01). Women whose baseline BMI Z-scores (at ages 8-10 years) were in the top quartile had significantly lower adult breast density, after adjusting for current adult BMI and other covariates [least squares mean (LSM): 23.4 %; 95 % confidence interval (CI): 18.0 %, 28.8 %] compared to those in the bottom quartile (LSM: 31.8 %; 95 % CI: 25.2 %, 38.4 %) (p trend <0.01). Significant inverse associations were also observed for absolute dense breast volume (all p values <0.01), whereas there were no clear associations with non-dense breast volume. These results support the hypothesis that body fatness during childhood and adolescence may play an important role in premenopausal breast density, independent of current BMI, and further suggest direct or indirect influences on absolute dense breast volume. NCT00458588 ; April 9, 2007.

Body Mass Index

Prospective Studies

Age Factors

Follow-Up Studies

Humans

Breast Neoplasms

Magnetic Resonance Imaging

Adiposity

Mammary Glands, Human - abnormalities

Adult

Female

Breast Density

Adipose Tissue

Child

Details

Title: Subtitle: Body fatness during childhood and adolescence and breast density in young women: a prospective analysis
Creators: Kimberly A Bertrand - Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. kbertran@hsph.harvard.edu
Heather J Baer - Division of General Internal Medicine and Primary Care, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02120, USA. hbaer@partners.org
E John Orav - Department of Biostatistics, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. eorav@partners.org
Catherine Klifa - Dangeard Group, 740 chemin de la Commanderie St Jean de Malte, 13080, Luynes, France. catherine@dangeard.com
John A Shepherd - Department of Radiology, University of California, 505 Parnassus Avenue, San Francisco, CA, 94143, USA. john.shepherd@ucsf.edu
Linda Van Horn - Department of Preventive Medicine, Northwestern University, 680 North Lake Shore Drive, Chicago, IL, 60611, USA. lvanhorn@northwestern.edu
Linda Snetselaar - Department of Epidemiology, University of Iowa College of Public Health, 145 North Riverside Drive, Iowa City, IA, 52242, USA. linda-snetselaar@uiowa.edu
Victor J Stevens - Kaiser Permanente Center for Health Research, 3800 North Interstate Avenue, Portland, OR, 97227, USA. Victor.J.Stevens@kpchr.org
Nola M Hylton - Department of Radiology, University of California, 505 Parnassus Avenue, San Francisco, CA, 94143, USA. Nola.Hylton@ucsf.edu
Joanne F Dorgan - Department of Epidemiology and Public Health, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD, 21201, USA. JDorgan@som.umaryland.edu
Resource Type: Journal article
Publication Details: Breast cancer research : BCR, Vol.17(1), pp.95-95
DOI: 10.1186/s13058-015-0601-4
PMID: 26174168
PMCID: PMC4502611
NLM abbreviation: Breast Cancer Res
ISSN: 1465-5411
eISSN: 1465-542X
Publisher: England
Grant note: R01CA104670 / NCI NIH HHS R25 CA098566 / NCI NIH HHS K01 HS019789 / AHRQ HHS R01 CA116182 / NCI NIH HHS R01 CA104670 / NCI NIH HHS R01CA116182 / NCI NIH HHS
Language: English
Date published: 07/16/2015
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9983995036602771

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