Body mass index and risk of second primary breast cancer: the WECARE Study

Jennifer D Brooks; Esther M John; Lene Mellemkjær; Anne S Reiner; Kathleen E Malone; Charles F Lynch; Jane C Figueiredo; Robert W Haile; Roy E Shore; Jonine L Bernstein; Leslie Bernstein; WECARE Study Collaborative Group

doi:10.1007/s10549-011-1743-4

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Body mass index and risk of second primary breast cancer: the WECARE Study

Journal article

Peer reviewed

Body mass index and risk of second primary breast cancer: the WECARE Study

Jennifer D Brooks, Esther M John, Lene Mellemkjær, Anne S Reiner, Kathleen E Malone, Charles F Lynch, Jane C Figueiredo, Robert W Haile, Roy E Shore, Jonine L Bernstein, …

Breast cancer research and treatment, Vol.131(2), pp.571-580

01/2012

DOI: 10.1007/s10549-011-1743-4

PMCID: PMC3251700

PMID: 21892703

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https://www.ncbi.nlm.nih.gov/pmc/articles/3251700View

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Abstract

The identification of potentially modifiable risk factors, such as body size, could allow for interventions that could help reduce the burden of contralateral breast cancer (CBC) among breast cancer survivors. Studies examining the relationship between body mass index (BMI) and CBC have yielded mixed results. From the population-based, case-control, Women's Environmental, Cancer and Radiation Epidemiology (WECARE) Study, we included 511 women with CBC (cases) and 999 women with unilateral breast cancer (controls) who had never used postmenopausal hormone therapy. Rate ratios (RR) and 95% confidence intervals (CI) were used to assess the relationship between BMI and CBC risk. No associations between BMI at first diagnosis or weight-change between first diagnosis and date of CBC diagnosis (or corresponding date in matched controls) and CBC risk were seen. However, obese (BMI ≥ 30 kg/m(2)) postmenopausal women with estrogen receptor (ER)-negative first primary tumors (n = 12 cases and 9 controls) were at an increased risk of CBC compared with normal weight women (BMI < 25 kg/m(2)) (n = 43 cases and 98 controls) (RR = 5.64 (95% CI 1.76, 18.1)). No association between BMI and CBC risk was seen in premenopausal or postmenopausal women with ER-positive first primaries. Overall, BMI is not associated with CBC risk in this population of young breast cancer survivors. Our finding of an over five-fold higher risk of CBC in a small subgroup of obese postmenopausal women with an ER-negative first primary breast cancer is based on limited numbers and requires confirmation in a larger study.

Body Mass Index

Young Adult

Risk Assessment

Humans

Middle Aged

Risk Factors

Adult

Female

Aged

Case-Control Studies

Breast Neoplasms - epidemiology

Neoplasms, Second Primary - epidemiology

Details

Title: Subtitle: Body mass index and risk of second primary breast cancer: the WECARE Study
Creators: Jennifer D Brooks - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 307 E 63rd Street, 3rd Floor, New York, NY, USA. brooksj@mskcc.org
Esther M John
Lene Mellemkjær
Anne S Reiner
Kathleen E Malone
Charles F Lynch
Jane C Figueiredo
Robert W Haile
Roy E Shore
Jonine L Bernstein
Leslie Bernstein
WECARE Study Collaborative Group
Resource Type: Journal article
Publication Details: Breast cancer research and treatment, Vol.131(2), pp.571-580
DOI: 10.1007/s10549-011-1743-4
PMID: 21892703
PMCID: PMC3251700
NLM abbreviation: Breast Cancer Res Treat
ISSN: 1573-7217
eISSN: 1573-7217
Publisher: Netherlands
Grant note: R01 CA129639 / NCI NIH HHS U01 CA083178 / NCI NIH HHS R01 CA114236-04 / NCI NIH HHS P30 CA015704 / NCI NIH HHS R01CA114236 / NCI NIH HHS U01CA083178 / NCI NIH HHS R01 CA114236 / NCI NIH HHS
Language: English
Date published: 01/2012
Academic Unit: Epidemiology
Record Identifier: 9983995138002771

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