Body mass index and survival of patients with lymphoma

Dai Chihara; Melissa C. Larson; Dennis P. Robinson; Carrie A. Thompson; Matthew J. Maurer; Carla Casulo; Priyanka Pophali; Brian K. Link; Thomas M. Habermann; Andrew L. Feldman; Christopher R. Flowers; James R. Cerhan; Lindsay M. Morton

doi:10.1080/10428194.2021.1929956

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Body mass index and survival of patients with lymphoma

Journal article

Open access

Peer reviewed

Body mass index and survival of patients with lymphoma

Dai Chihara, Melissa C. Larson, Dennis P. Robinson, Carrie A. Thompson, Matthew J. Maurer, Carla Casulo, Priyanka Pophali, Brian K. Link, Thomas M. Habermann, Andrew L. Feldman, …

Leukemia & lymphoma, Vol.62(11), pp.2671-2678

09/19/2021

DOI: 10.1080/10428194.2021.1929956

PMCID: PMC8771423

PMID: 34121594

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https://www.ncbi.nlm.nih.gov/pmc/articles/8771423View

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Abstract

The impact of body mass index (BMI) on survival in lymphoma remains controversial. We leveraged a prospective cohort of lymphoma patients enrolled to SPORE Molecular Epidemiology Resource between 2002 and 2015 to assess the association of BMI before diagnosis, BMI at diagnosis, and BMI change over time with lymphoma-specific survival (LSS). A total of 4009 lymphoma patients (670 diffuse large B-cell lymphoma (DLBCL), 689 follicular lymphoma (FL), 1018 chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and 1632 other subtypes) were included. Significantly shorter LSS after diagnosis was observed for FL patients who were obese before diagnosis (HR: 3.02, 95%CI: 1.43-6.41, p=.004) and for those with a ≥ 5% increase in BMI from diagnosis to 3-year follow-up (HR: 3.53, 95%CI: 1.22-10.2, p=.020). In contrast, obesity prior to or at the time of diagnosis was not associated with LSS in DLBCL and CLL/SLL. The impact of weight control after diagnosis in FL patient warrants investigation.

body mass index

CLL/SLL

Diffuse large B-cell lymphoma

follicular lymphoma

survival

Details

Title: Subtitle: Body mass index and survival of patients with lymphoma
Creators: Dai Chihara - The University of Texas MD Anderson Cancer Center
Melissa C. Larson - Mayo Clinic in Florida
Dennis P. Robinson - Mayo Clinic in Florida
Carrie A. Thompson - Mayo Clinic
Matthew J. Maurer - Department of Health Sciences Research, Mayo Clinic
Carla Casulo - University of Rochester Medical Center
Priyanka Pophali - University of Wisconsin–Madison
Brian K. Link - University of Iowa
Thomas M. Habermann - Mayo Clinic
Andrew L. Feldman - Mayo Clinic
Christopher R. Flowers - The University of Texas MD Anderson Cancer Center
James R. Cerhan - Mayo Clinic in Florida
Lindsay M. Morton - National Cancer Institute
Resource Type: Journal article
Publication Details: Leukemia & lymphoma, Vol.62(11), pp.2671-2678
DOI: 10.1080/10428194.2021.1929956
PMID: 34121594
PMCID: PMC8771423
NLM abbreviation: Leuk Lymphoma
ISSN: 1042-8194
eISSN: 1029-2403
Publisher: Taylor & Francis
Grant note: name: Lymphoma SPORE, award: CA0972474
Language: English
Date published: 09/19/2021
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
Record Identifier: 9984359784302771

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