Journal article
Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative
Gynecologic oncology, Vol.133(1), pp.4-10
04/01/2014
DOI: 10.1016/j.ygyno.2014.01.033
PMCID: PMC4064800
PMID: 24680584
Abstract
Background. Ovarian cancer is often diagnosed at late stages and consequently the 5-year survival rate is only 44%. However, there is limited knowledge of the association of modifiable lifestyle factors, such as physical activity and obesity on mortality among women diagnosed with ovarian cancer. The purpose of our study was to prospectively investigate the association of (1) measured body mass index (BMI), and (2) self-reported physical activity with ovarian cancer-specific and all-cause mortality in postmenopausal women enrolled in the Women's Health Initiative (WHI).
Methods. Participants were 600 women diagnosed with primary ovarian cancer subsequent to enrollment in WHI. Exposure data, including measured height and weight and reported physical activity from recreation and walking, used in this analysis were ascertained at the baseline visit for the WHI. Cox proportional hazard regression was used to examine the associations between BMI, physical activity and mortality endpoints.
Results. Vigorous-intensity physical activity was associated with a 26% lower risk of ovarian cancer specific-mortality (HR = 0.74; 95% CI: 0.56-0.98) and a 24% lower risk of all-cause mortality (HR = 0.76; 95% CI: 0.58-0.98) compared to no vigorous-intensity physical activity. BMI was not associated with mortality.
Conclusions. Participating in vigorous-intensity physical activity, assessed prior to ovarian cancer diagnosis, appears to be associated with a lower risk of ovarian cancer mortality. (C) 2014 Elsevier Inc. All rights reserved.
Details
- Title: Subtitle
- Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative
- Creators
- Yang Zhou - Yale UniversityRowan Chlebowski - University of California, Los AngelesMichael J. LaMonte - University at Buffalo, State University of New YorkJennifer W. Bea - University of ArizonaLihong Qi - University of California, DavisRobert Wallace - University of IowaSayeh Lavasani - The Barbara Ann Karmanos Cancer InstituteBrian W. Walsh - Brigham and Women's HospitalGarnet Anderson - University of WashingtonMara Vitolins - Wake Forest UniversityGloria Sarto - University of Wisconsin–MadisonMelinda L. Irwin - Yale University
- Resource Type
- Journal article
- Publication Details
- Gynecologic oncology, Vol.133(1), pp.4-10
- DOI
- 10.1016/j.ygyno.2014.01.033
- PMID
- 24680584
- PMCID
- PMC4064800
- NLM abbreviation
- Gynecol Oncol
- ISSN
- 0090-8258
- eISSN
- 1095-6859
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA HHSN268201100046C; HHSN268201100001C; HHSN268201100002C; HHSN268201100003C; HHSN268201100004C; HHSN271201100004C / U.S. Department of Health and Human Services National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) P30CA016359 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Language
- English
- Date published
- 04/01/2014
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984364428902771
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