Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancer

Jennifer D Brooks; Esther M John; Lene Mellemkjaer; Charles F Lynch; Julia A Knight; Kathleen E Malone; Anne S Reiner; Leslie Bernstein; Xiaolin Liang; Roy E Shore; Marilyn Stovall; Jonine L Bernstein; WECARE Study Collaborative Group

doi:10.1002/cam4.890

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Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancer

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Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancer

Jennifer D Brooks, Esther M John, Lene Mellemkjaer, Charles F Lynch, Julia A Knight, Kathleen E Malone, Anne S Reiner, Leslie Bernstein, Xiaolin Liang, Roy E Shore, …

Cancer medicine (Malden, MA), Vol.5(11), pp.3282-3291

11/2016

DOI: 10.1002/cam4.890

PMCID: PMC5119984

PMID: 27700016

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Abstract

Studies examining the relationship between body mass index (BMI) and risk of contralateral breast cancer (CBC) have reported mixed findings. We previously showed that obese postmenopausal women with estrogen receptor (ER)-negative breast cancer have a fivefold higher risk of CBC compared with normal weight women. In the current analysis, we reexamined this relationship in the expanded Women's Environmental Cancer and Radiation Epidemiology (WECARE) Study, focusing on the impact of menopausal status and ER status of the first breast cancer. The WECARE Study is a population-based case-control study of young women with CBC (cases, N = 1386) and with unilateral breast cancer (controls, N = 2045). Rate ratios (RR) and 95% confidence intervals (CI) were calculated to assess the relationship between BMI and risk of CBC stratified by menopausal and ER status. Positive associations with obesity and weight gain were limited to women who became postmenopausal following their first primary breast cancer. Among those with an ER-negative first breast cancer, obesity (vs. normal weight) at first diagnosis was associated with an increased risk of CBC (RR = 1.9, 95% CI: 1.02, 3.4). Also, weight gain of ≥10 kg after first diagnosis was associated with an almost twofold increased risk of CBC (RR = 1.9, 95% CI: 0.99, 3.8). These results suggest that women with an ER-negative first primary cancer who are obese at first primary diagnosis or who experience a large weight gain afterward may benefit from heightened surveillance. Future studies are needed to address the impact of weight loss interventions on risk of CBC.

Body Mass Index

Receptors, Estrogen - metabolism

SEER Program

Body Weight

Humans

Middle Aged

Breast Neoplasms - etiology

Risk

Case-Control Studies

Breast Neoplasms - metabolism

Neoplasms, Second Primary - epidemiology

Neoplasms, Second Primary - etiology

Young Adult

Breast Neoplasms - pathology

Adult

Female

Aged

Neoplasm Staging

Population Surveillance

Breast Neoplasms - epidemiology

Details

Title: Subtitle: Body mass index, weight change, and risk of second primary breast cancer in the WECARE study: influence of estrogen receptor status of the first breast cancer
Creators: Jennifer D Brooks - University of Toronto, Dalla Lana School of Public Health Sciences, Toronto, Canada
Esther M John - Department of Health Research and Policy (Epidemiology), Stanford University School of Medicine, Stanford, California
Lene Mellemkjaer - Danish Cancer Society Research Center, Copenhagen, Denmark
Charles F Lynch - University of Iowa, Iowa City, Iowa
Julia A Knight - Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada
Kathleen E Malone - Fred Hutchinson Cancer Research Center, Seattle, Washington
Anne S Reiner - Memorial Sloan Kettering Cancer Center, New York, New York
Leslie Bernstein - Beckman Research Institute, City of Hope National Medical Center, Duarte, California
Xiaolin Liang - Memorial Sloan Kettering Cancer Center, New York, New York
Roy E Shore - Department of Population Health, New York University School of Medicine, New York, New York
Marilyn Stovall - The University of Texas MD Anderson Cancer Center, Houston, Texas
Jonine L Bernstein - Memorial Sloan Kettering Cancer Center, New York, New York
WECARE Study Collaborative Group
Resource Type: Journal article
Publication Details: Cancer medicine (Malden, MA), Vol.5(11), pp.3282-3291
DOI: 10.1002/cam4.890
PMID: 27700016
PMCID: PMC5119984
NLM abbreviation: Cancer Med
ISSN: 2045-7634
eISSN: 2045-7634
Publisher: United States
Grant note: R01 CA129639 / NCI NIH HHS R01 CA097397 / NCI NIH HHS U01 CA083178 / NCI NIH HHS P30 CA008748 / NCI NIH HHS P30 CA086862 / NCI NIH HHS R01 CA114236 / NCI NIH HHS
Language: English
Date published: 11/2016
Academic Unit: Epidemiology
Record Identifier: 9983995157902771

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