Bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness

S.S Khalsa; D Rudrauf; C Sandesara; B Olshansky; D Tranel

doi:10.1016/j.ijpsycho.2008.08.010

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Bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness

Journal article

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Bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness

S.S Khalsa, D Rudrauf, C Sandesara, B Olshansky and D Tranel

International journal of psychophysiology, Vol.72(1), pp.34-45

2009

DOI: 10.1016/j.ijpsycho.2008.08.010

PMCID: PMC3085829

PMID: 18854201

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https://www.ncbi.nlm.nih.gov/pmc/articles/3085829View

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Abstract

Interoception, defined as the perception of internal body states, plays a central role in classic and contemporary theories of emotion. In particular, deviations from baseline body states have been hypothesized to be integral to the experience of emotion and feeling. Consequently, reliable measurement of interoception is critical to the testing of emotion theories. Heartbeat perception tasks have been considered the standard method for assessing interoceptive awareness, primarily due to their non-invasive nature and technical feasibility. However, these tasks are limited by the fact that above chance group performance rates on heartbeat detection (or the frequency of ‘good detectors’) are rarely higher than 40%, meaning that such tasks (as they are typically utilized) do not obtain a measure of interoceptive awareness in the majority of individuals. Here we describe a novel protocol for inducing and assessing a range of deviations in body states via bolus infusions of isoproterenol, a non-selective beta adrenergic agonist. Using a randomized, double-blinded, and placebo-controlled experimental design, we found that bolus isoproterenol infusions elicited rapid and transient increases in heart rate and concomitant ratings of heartbeat and breathing sensations, in a dose-dependent manner. Our protocol revealed changes in interoceptive awareness in all 15 participants tested, thus overcoming a major limitation of heartbeat detection tasks. These findings indicate that bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness, which sets a foundation for further investigation of the role of interoceptive sensations in the experience of emotion.

Emotion

Interoception

Isoproterenol

Respiration

Heartbeat detection

Details

Title: Subtitle: Bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness
Creators: S.S Khalsa - Department of Neurology (Division of Behavioral Neurology and Cognitive Neuroscience) and Neuroscience Program, University of Iowa, United States
D Rudrauf - Department of Neurology (Division of Behavioral Neurology and Cognitive Neuroscience) and Neuroscience Program, University of Iowa, United States
C Sandesara - Department of Internal Medicine (Division of Cardiology), University of Iowa, United States
B Olshansky - Department of Internal Medicine (Division of Cardiology), University of Iowa, United States
D Tranel - Department of Neurology (Division of Behavioral Neurology and Cognitive Neuroscience) and Neuroscience Program, University of Iowa, United States
Resource Type: Journal article
Publication Details: International journal of psychophysiology, Vol.72(1), pp.34-45
DOI: 10.1016/j.ijpsycho.2008.08.010
PMID: 18854201
PMCID: PMC3085829
NLM abbreviation: Int J Psychophysiol
ISSN: 0167-8760
eISSN: 1872-7697
Publisher: Elsevier B.V
Language: English
Date published: 2009
Academic Unit: Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Internal Medicine
Record Identifier: 9984002425302771

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