Journal article
Bone Complications Among Prostate Cancer Survivors: Long-Term Follow-Up From the Prostate Cancer Outcomes Study
Prostate cancer and prostatic diseases, Vol.17(4), pp.338-342
12/2014
DOI: 10.1038/pcan.2014.31
PMCID: PMC4227957
PMID: 25134939
Abstract
Background: To assess the relationship between androgen deprivation therapy (ADT) exposure and self-reported bone complications among men in a population-based cohort of prostate cancer survivors followed for 15 years after diagnosis.
Methods: The Prostate Cancer Outcomes Study enrolled 3533 patients diagnosed with prostate cancer between 1994 and 1995. This analysis included participants with non-metastatic disease at the time of diagnosis who completed 15-year follow-up surveys to report development of fracture, and use of bone-related medications. The relationship between ADT duration and bone complications was assessed using multivariable logistic regression models.
Results: Among 961 surviving men, 157 (16.3%) received prolonged ADT (>1 year), 120 (12.5%) received short-term ADT (⩽ 1 year) and 684 (71.2%) did not receive ADT. Men receiving prolonged ADT had higher odds of fracture (OR 2.5; 95% confidence interval (CI): 1.1-5.7), bone mineral density testing (OR 5.9; 95% CI: 3.0-12) and bone medication use (OR 4.3; 95% CI: 2.3-8.0) than untreated men. Men receiving short-term ADT reported rates of fracture similar to untreated men. Half of men treated with prolonged ADT reported bone medication use.
Conclusions: In this population-based cohort study with long-term follow-up, prolonged ADT use was associated with substantial risks of fracture, whereas short-term use was not. This information should be considered when weighing the advantages and disadvantages of ADT in men with prostate cancer.
Details
- Title: Subtitle
- Bone Complications Among Prostate Cancer Survivors: Long-Term Follow-Up From the Prostate Cancer Outcomes Study
- Creators
- Alicia K Morgans - Vanderbilt University School of Medicine, Nashville, TNKang-Hsien Fan - Vanderbilt University School of Medicine, Nashville, TNTatsuki Koyama - Vanderbilt University School of Medicine, Nashville, TNPeter C Albertsen - University of Connecticut Health Center, Farmington, CTMichael Goodman - Emory University, Atlanta, GAAnn S Hamilton - Keck School of Medicine, University of Southern California, Los Angeles, CARichard M Hoffman - University of New Mexico, Albuquerque, NMJanet L Stanford - Fred Hutchinson Cancer Research Center, Seattle, WAAntoinette M Stroup - University of Utah, Salt Lake City, UTDavid F Penson - Vanderbilt University School of Medicine, Nashville, TN
- Resource Type
- Journal article
- Publication Details
- Prostate cancer and prostatic diseases, Vol.17(4), pp.338-342
- DOI
- 10.1038/pcan.2014.31
- PMID
- 25134939
- PMCID
- PMC4227957
- ISSN
- 1365-7852
- eISSN
- 1476-5608
- Language
- English
- Date published
- 12/2014
- Academic Unit
- Epidemiology; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984094336102771
Metrics
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