Bone Marrow-Derived Cells as a Therapeutic Approach to Optic Nerve Diseases

Louise A. Mesentier-Louro; Camila Zaverucha-do-Valle; Paulo H. Rosado-de-Castro; Almir J. Silva-Junior; Pedro M. Pimentel-Coelho; Rosalia Mendez-Otero; Marcelo F. Santiago

doi:10.1155/2016/5078619

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Bone Marrow-Derived Cells as a Therapeutic Approach to Optic Nerve Diseases

Journal article

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Bone Marrow-Derived Cells as a Therapeutic Approach to Optic Nerve Diseases

Louise A. Mesentier-Louro, Camila Zaverucha-do-Valle, Paulo H. Rosado-de-Castro, Almir J. Silva-Junior, Pedro M. Pimentel-Coelho, Rosalia Mendez-Otero and Marcelo F. Santiago

Stem cells international, Vol.2016(2016), pp.1-16

01/01/2016

DOI: 10.1155/2016/5078619

PMCID: PMC4663341

PMID: 26649049

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Abstract

Following optic nerve injury associated with acute or progressive diseases, retinal ganglion cells (RGCs) of adult mammals degenerate and undergo apoptosis. These diseases have limited therapeutic options, due to the low inherent capacity of RGCs to regenerate and due to the inhibitory milieu of the central nervous system. Among the numerous treatment approaches investigated to stimulate neuronal survival and axonal extension, cell transplantation emerges as a promising option. This review focuses on cell therapies with bone marrow mononuclear cells and bone marrow-derived mesenchymal stem cells, which have shown positive therapeutic effects in animal models of optic neuropathies. Different aspects of available preclinical studies are analyzed, including cell distribution, potential doses, routes of administration, and mechanisms of action. Finally, published and ongoing clinical trials are summarized.

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Title: Subtitle: Bone Marrow-Derived Cells as a Therapeutic Approach to Optic Nerve Diseases
Creators: Louise A. Mesentier-Louro - Universidade Federal do Rio de Janeiro
Camila Zaverucha-do-Valle - Fundação Oswaldo Cruz
Paulo H. Rosado-de-Castro - Universidade Federal do Rio de Janeiro
Almir J. Silva-Junior - Instituto de Biofísica Carlos Chagas Filho
Pedro M. Pimentel-Coelho - Universidade Federal do Rio de Janeiro
Rosalia Mendez-Otero - Universidade Federal do Rio de Janeiro
Marcelo F. Santiago - Universidade Federal do Rio de Janeiro
Resource Type: Journal article
Publication Details: Stem cells international, Vol.2016(2016), pp.1-16
DOI: 10.1155/2016/5078619
PMID: 26649049
PMCID: PMC4663341
NLM abbreviation: Stem Cells Int
ISSN: 1687-966X
eISSN: 1687-9678
Publisher: Hindawi Publishing Corporation
Language: English
Date published: 01/01/2016
Academic Unit: Radiology
Record Identifier: 9985143551002771

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