Bone and brain: a review of neural, hormonal, and musculoskeletal connections

Kevin B Jones; Anthony V Mollano; Jose A Morcuende; Reginald R Cooper; Charles L Saltzman

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Bone and brain: a review of neural, hormonal, and musculoskeletal connections

Journal article

Open access

Peer reviewed

Bone and brain: a review of neural, hormonal, and musculoskeletal connections

Kevin B Jones, Anthony V Mollano, Jose A Morcuende, Reginald R Cooper and Charles L Saltzman

The Iowa orthopaedic journal, Vol.24, pp.123-132

2004

PMCID: PMC1888423

PMID: 15296219

Appears in Diamond Open Access

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1888423/View

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Abstract

Nerves have been identified in bone. Their function has recently become the focus of intense study. Metabolic control of bone is influenced by the nervous system. Potential transmitters of this influence include glutamate, calcitonin gene-related protein (CGRP), substance P, vasoactive intestinal peptide (VIP), pituitary adenylate cyclase activating polypeptide (PACAP), leptin, and catecholamines. Disorders of nerves - central or peripheral--can have substantial influence on bone health and repair. Specifically considered are the potential neural influences at work in such conditions as osteoporosis, fracture healing, Charcot osteoarthropathy, musculoskeletal pain syndromes, heterotopic ossification, skeletal growth and development, and obesity-related increased bone density. In this article, we review the current state of experimental and clinical evidence implicating the role of nervous tissue in regulating bone biology and discuss the current understanding of molecular signaling between nervous and osseus tissue in the homeostatic maintenance of the skeleton.

Vasoactive Intestinal Peptide - metabolism

Catecholamines - metabolism

Humans

Neuropeptides - metabolism

Peripheral Nervous System Diseases - physiopathology

Brain - metabolism

Arthropathy, Neurogenic - physiopathology

Bone and Bones - metabolism

Substance P - metabolism

Glutamic Acid - metabolism

Bone and Bones - innervation

Calcitonin Gene-Related Peptide - metabolism

Central Nervous System Diseases - physiopathology

Denervation

Details

Title: Subtitle: Bone and brain: a review of neural, hormonal, and musculoskeletal connections
Creators: Kevin B Jones - Department of Orthopaedics and Rehabilitation, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
Anthony V Mollano
Jose A Morcuende
Reginald R Cooper
Charles L Saltzman
Resource Type: Journal article
Publication Details: The Iowa orthopaedic journal, Vol.24, pp.123-132
Publisher: Dept. of Orthopaedics, The University of Iowa; United States
PMID: 15296219
PMCID: PMC1888423
ISSN: 1541-5457
eISSN: 1555-1377
Language: English
Date published: 2004
Academic Unit: Stead Family Department of Pediatrics; Orthopedics and Rehabilitation
Record Identifier: 9984040537002771

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