Journal article
Bone and non-contractile soft tissue changes following open kinetic chain resistance training and testosterone treatment in spinal cord injury: an exploratory study
Osteoporosis international, Vol.32(7), pp.1321-1332
01/14/2021
DOI: 10.1007/s00198-020-05778-2
PMID: 33443609
Abstract
Summary
Twenty men with spinal cord injury (SCI) were randomized into two 16-week intervention groups receiving testosterone treatment (TT) or TT combined with resistance training (TT + RT). TT + RT appears to hold the potential to reverse or slow down bone loss following SCI if provided over a longer period.
Introduction
Persons with SCI experience bone loss below the level of injury. The combined effects of resistance training and TT on bone quality following SCI remain unknown.
Methods
Men with SCI were randomized into 16-week treatments receiving TT or TT + RT. Magnetic resonance imaging (MRI) of the right lower extremity before participation and post-intervention was used to visualize the proximal, middle, and distal femoral shaft, the quadriceps tendon, and the intermuscular fascia of the quadriceps. For the TT + RT group, MRI microarchitecture techniques were utilized to elucidate trabecular changes around the knee. Individual mixed models were used to estimate effect sizes.
Results
Twenty participants completed the pilot trial. A small effect for yellow marrow in the distal femur was indicated as increases following TT and decreases following TT + RT were observed. Another small effect was observed as the TT + RT group displayed greater increases in intermuscular fascia length than the TT arm. Distal femur trabecular changes for the TT + RT group were generally small in effect (decreased trabecular thickness variability, spacing, and spacing variability; increased network area). Medium effects were generally observed in the proximal tibia (increased plate width, trabecular thickness, and network area; decreased trabecular spacing and spacing variability).
Conclusions
This pilot suggests longer TT + RT interventions may be a viable rehabilitation technique to combat bone loss following SCI.
Clinical trial registration
Registered with
clinicaltrials.gov
: NCT01652040 (07/27/2012).
Details
- Title: Subtitle
- Bone and non-contractile soft tissue changes following open kinetic chain resistance training and testosterone treatment in spinal cord injury: an exploratory study
- Creators
- M.E Holman - Spinal Cord Injury and Disorders, Hunter Holmes McGuire VAMC, Richmond, VA, 23249, USA.G Chang - New York UniversityM.P Ghatas - Spinal Cord Injury and Disorders, Hunter Holmes McGuire VAMC, Richmond, VA, 23249, USA.P.K Saha - University of IowaX Zhang - University of IowaM.R Khan - Department of Radiology, Hunter Holmes McGuire VAMC, Richmond, VA, 23249, USA.A.P Sima - Virginia Commonwealth UniversityR.A Adler - Spinal Cord Injury and Disorders, Hunter Holmes McGuire VAMC, Richmond, VA, 23249, USA.A. S Gorgey - Virginia Commonwealth University
- Resource Type
- Journal article
- Publication Details
- Osteoporosis international, Vol.32(7), pp.1321-1332
- Publisher
- Springer London
- DOI
- 10.1007/s00198-020-05778-2
- PMID
- 33443609
- ISSN
- 0937-941X
- eISSN
- 1433-2965
- Grant note
- B7867-W / U.S. Department of Veterans Affairs (http://dx.doi.org/10.13039/100000738)
- Language
- English
- Date published
- 01/14/2021
- Academic Unit
- Radiology; Electrical and Computer Engineering
- Record Identifier
- 9984198015602771
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