Bone architecture adaptations after spinal cord injury: impact of long-term vibration of a constrained lower limb

S Dudley-Javoroski; M A Petrie; C L McHenry; R E Amelon; P K Saha; R K Shields

doi:10.1007/s00198-015-3326-4

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Bone architecture adaptations after spinal cord injury: impact of long-term vibration of a constrained lower limb

Journal article

Open access

Peer reviewed

Bone architecture adaptations after spinal cord injury: impact of long-term vibration of a constrained lower limb

S Dudley-Javoroski, M A Petrie, C L McHenry, R E Amelon, P K Saha and R K Shields

Osteoporosis international, Vol.27(3), pp.1149-1160

03/2016

DOI: 10.1007/s00198-015-3326-4

PMCID: PMC4767656

PMID: 26395887

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https://www.ncbi.nlm.nih.gov/pmc/articles/4767656View

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Abstract

This study examined the effect of a controlled dose of vibration upon bone density and architecture in people with spinal cord injury (who eventually develop severe osteoporosis). Very sensitive computed tomography (CT) imaging revealed no effect of vibration after 12 months, but other doses of vibration may still be useful to test. The purposes of this report were to determine the effect of a controlled dose of vibratory mechanical input upon individual trabecular bone regions in people with chronic spinal cord injury (SCI) and to examine the longitudinal bone architecture changes in both the acute and chronic state of SCI. Participants with SCI received unilateral vibration of the constrained lower limb segment while sitting in a wheelchair (0.6g, 30 Hz, 20 min, three times weekly). The opposite limb served as a control. Bone mineral density (BMD) and trabecular micro-architecture were measured with high-resolution multi-detector CT. For comparison, one participant was studied from the acute (0.14 year) to the chronic state (2.7 years). Twelve months of vibration training did not yield adaptations of BMD or trabecular micro-architecture for the distal tibia or the distal femur. BMD and trabecular network length continued to decline at several distal femur sub-regions, contrary to previous reports suggesting a "steady state" of bone in chronic SCI. In the participant followed from acute to chronic SCI, BMD and architecture decline varied systematically across different anatomical segments of the tibia and femur. This study supports that vibration training, using this study's dose parameters, is not an effective anti-osteoporosis intervention for people with chronic SCI. Using a high-spatial-resolution CT methodology and segmental analysis, we illustrate novel longitudinal changes in bone that occur after spinal cord injury.

Bone Density - physiology

Spinal Cord Injuries - complications

Humans

Child, Preschool

Tomography, X-Ray Computed - methods

Infant

Male

Femur - diagnostic imaging

Osteoporosis - etiology

Young Adult

Cancellous Bone - diagnostic imaging

Osteoporosis - diagnostic imaging

Adult

Female

Child

Osteoporosis - physiopathology

Tibia - physiopathology

Osteoporosis - prevention & control

Tibia - diagnostic imaging

Femur - physiopathology

Adolescent

Lower Extremity

Vibration - therapeutic use

Spinal Cord Injuries - physiopathology

Longitudinal Studies

Details

Title: Subtitle: Bone architecture adaptations after spinal cord injury: impact of long-term vibration of a constrained lower limb
Creators: S Dudley-Javoroski - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, 1-252 Medical Education Building, Iowa City, IA, 52242, USA
M A Petrie - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, 1-252 Medical Education Building, Iowa City, IA, 52242, USA
C L McHenry - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, 1-252 Medical Education Building, Iowa City, IA, 52242, USA
R E Amelon - Department of Electrical and Computer Engineering, The University of Iowa, Iowa City, IA, USA
P K Saha - Department of Radiology, Carver College of Medicine, The University of Iowa, Iowa City, IA, USA
R K Shields - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, 1-252 Medical Education Building, Iowa City, IA, 52242, USA. richard-shields@uiowa.edu
Resource Type: Journal article
Publication Details: Osteoporosis international, Vol.27(3), pp.1149-1160
DOI: 10.1007/s00198-015-3326-4
PMID: 26395887
PMCID: PMC4767656
NLM abbreviation: Osteoporos Int
ISSN: 0937-941X
eISSN: 1433-2965
Publisher: England
Grant note: R01HD062507 / NICHD NIH HHS R01 HD062507 / NICHD NIH HHS S10 OD018526 / NIH HHS
Language: English
Date published: 03/2016
Academic Unit: Radiology; Electrical and Computer Engineering; Orthopedics and Rehabilitation; Physical Therapy and Rehabilitation Science
Record Identifier: 9984046821302771

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