Journal article
Bone repair cells for craniofacial regeneration
Advanced drug delivery reviews, Vol.64(12), pp.1310-1319
09/2012
DOI: 10.1016/j.addr.2012.03.005
PMCID: PMC3383887
PMID: 22433781
Abstract
Reconstruction of complex craniofacial deformities is a clinical challenge in situations of injury, congenital defects or disease. The use of cell-based therapies represents one of the most advanced methods for enhancing the regenerative response for craniofacial wound healing. Both somatic and stem cells have been adopted in the treatment of complex osseous defects and advances have been made in finding the most adequate scaffold for the delivery of cell therapies in human regenerative medicine. As an example of such approaches for clinical application for craniofacial regeneration, Ixmyelocel-T or bone repair cells are a source of bone marrow derived stem and progenitor cells. They are produced through the use of single pass perfusion bioreactors for CD90+ mesenchymal stem cells and CD14+ monocyte/macrophage progenitor cells. The application of ixmyelocel-T has shown potential in the regeneration of muscular, vascular, nervous and osseous tissue. The purpose of this manuscript is to highlight cell therapies used to repair bony and soft tissue defects in the oral and craniofacial complex. The field at this point remains at an early stage, however this review will provide insights into the progress being made using cell therapies for eventual development into clinical practice.\n[Display omitted]
Details
- Title: Subtitle
- Bone repair cells for craniofacial regeneration
- Creators
- G Pagni - Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, University of Michigan, 1011 N. University Ave., Ann Arbor, MI 48109-1078, USAD Kaigler - Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, University of Michigan, 1011 N. University Ave., Ann Arbor, MI 48109-1078, USAG Rasperini - Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, University of Michigan, 1011 N. University Ave., Ann Arbor, MI 48109-1078, USAG Avila-Ortiz - Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, University of Michigan, 1011 N. University Ave., Ann Arbor, MI 48109-1078, USAR Bartel - Aastrom Biosciences, Inc. Ann Arbor, 24 Frank Lloyd Wright Dr. Lobby K Ann Arbor, MI 48105, USAW.V Giannobile - Department of Periodontics and Oral Medicine and Michigan Center for Oral Health Research, University of Michigan, 1011 N. University Ave., Ann Arbor, MI 48109-1078, USA
- Resource Type
- Journal article
- Publication Details
- Advanced drug delivery reviews, Vol.64(12), pp.1310-1319
- Publisher
- Elsevier B.V
- DOI
- 10.1016/j.addr.2012.03.005
- PMID
- 22433781
- PMCID
- PMC3383887
- ISSN
- 0169-409X
- eISSN
- 1872-8294
- Language
- English
- Date published
- 09/2012
- Academic Unit
- Periodontics
- Record Identifier
- 9984066092302771
Metrics
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