Boosting NAD to spare hearing

Charles Brenner

doi:10.1016/j.cmet.2014.11.015

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Journal article

Open access

Peer reviewed

Boosting NAD to spare hearing

Charles Brenner

Cell metabolism, Vol.20(6), pp.926-927

12/02/2014

DOI: 10.1016/j.cmet.2014.11.015

PMID: 25470539

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https://doi.org/10.1016/j.cmet.2014.11.015View

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Abstract

Ex vivo experiments have strangely shown that inhibition or stimulation of NAD metabolism can be neuroprotective. In this issue of Cell Metabolism, Brown et al. (2014) demonstrate that cochlear NAD is diminished by deafening noise but protected by nicotinamide riboside or WldS mutation. Hearing protection by nicotinamide riboside depends on Sirt3.

Niacinamide - analogs & derivatives

NAD - therapeutic use

Animals

Sirtuin 3 - metabolism

Female

Male

Hearing Loss, Noise-Induced - prevention & control

Details

Title: Subtitle: Boosting NAD to spare hearing
Creators: Charles Brenner - Roy J. Carver Chair of Biochemistry and Professor of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. Electronic address: charles-brenner@uiowa.edu
Resource Type: Journal article
Publication Details: Cell metabolism, Vol.20(6), pp.926-927
Publisher: United States
DOI: 10.1016/j.cmet.2014.11.015
PMID: 25470539
ISSN: 1932-7420
eISSN: 1932-7420
Language: English
Date published: 12/02/2014
Academic Unit: Biochemistry and Molecular Biology; Internal Medicine
Record Identifier: 9983788599902771

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