Boosting enrollment in neurology trials with Local Identification and Outreach Networks (LIONs)

W. N KERNAN; C. M VISCOLI; D. M BRAVATA; S EISEN; L RESOR; K SENA; D STORY; L. M BRASS; K. L FURIE; L GUTMANN; E HINNAU; M GORMAN; D DEMARCO; A. M LOVEJOY; S. E INZUCCHI; L. H YOUNG; R. I HORWITZ; B MENDES; K SHRAUGER; J. L SCHINDLER; J. C MCVEETY; A SICKLICK; D MOALLI; P GRECO

doi:10.1212/WNL.0b013e3181a0fda3

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Boosting enrollment in neurology trials with Local Identification and Outreach Networks (LIONs)

Journal article

Open access

Peer reviewed

Boosting enrollment in neurology trials with Local Identification and Outreach Networks (LIONs)

W. N KERNAN, C. M VISCOLI, D. M BRAVATA, S EISEN, L RESOR, K SENA, D STORY, L. M BRASS, K. L FURIE, L GUTMANN, …

Neurology, Vol.72(15), pp.1345-1351

2009

DOI: 10.1212/WNL.0b013e3181a0fda3

PMCID: PMC2677492

PMID: 19365056

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https://europepmc.org/articles/pmc2677492View

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Abstract

Objective: Our purpose was to develop a geographically localized, multi-institution strategy for improving enrolment in a trial of secondary stroke prevention. Methods: We invited 11 Connecticut hospitals to participate in a project named the Local Identification and Outreach Network (LION). Each hospital provided the names of patients with stroke or TIA, identified from electronic admission or discharge logs, to researchers at a central coordinating center. After obtaining permission from personal physicians, researchers contacted each patient to describe the study, screen for eligibility, and set up a home visit for consent. Researchers traveled throughout the state to enroll and follow participants. Outside the LION, investigators identified trial participants using conventional recruitment strategies. We compared recruitment success for the LION and other sites using data from January 1, 2005, through June 30, 2007. Results: The average monthly randomization rate from the LION was 4.0 participants, compared with 0.46 at 104 other Insulin Resistance Intervention after Stroke (IRIS) sites. The LION randomized on average 1.52/1,000 beds/month, compared with 0.76/1,000 beds/month at other IRIS sites (p = 0.03). The average cost to randomize and follow one participant was $8,697 for the LION, compared with $7,198 for other sites. Conclusion: A geographically based network of institutions, served by a central coordinating center, randomized substantially more patients per month compared with sites outside of the network. The high enrollment rate was a result of surveillance at multiple institutions and greater productivity at each institution. Although the cost per patient was higher for the network, compared with nonnetwork sites, cost savings could result from more rapid completion of research.

Neurology

Biological and medical sciences

Nervous system as a whole

Medical sciences

Nervous system (semeiology, syndromes)

Details

Title: Subtitle: Boosting enrollment in neurology trials with Local Identification and Outreach Networks (LIONs)
Creators: W. N KERNAN - Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States
C. M VISCOLI - Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States
D. M BRAVATA - Richard L. Roudebush VAMC Indiana University School of Medicine, Indianapolis, IN, United States
S EISEN - Waterbury Hospital, Waterbury, CT, United States
L RESOR - Stamford Hospital, Stamford, CT, United States
K SENA - Bridgeport Hospital, Bridgeport, CT, United States
D STORY - Department of Neurology, Yale School of Medicine, New Haven, CT, United States
L. M BRASS - Department of Neurology, Yale School of Medicine, New Haven, CT, United States
K. L FURIE - Department of Medicine Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States
L GUTMANN - National Institute of Neurological Disorders and Stroke NIH, Bethesda, MD, United States
E HINNAU - Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States
M GORMAN - Department of Neurology University of Vermont, Burlington, VT, United States
D DEMARCO - Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States
A. M LOVEJOY - Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States
S. E INZUCCHI - Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States
L. H YOUNG - Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States
R. I HORWITZ - Department of Medicine Stanford University School of Medicine, Palo Alto, CA, United States
B MENDES - Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States
K SHRAUGER - Department of Internal Medicine, Yale School of Medicine, New Haven, CT, United States
J. L SCHINDLER - Department of Neurology, Yale School of Medicine, New Haven, CT, United States
J. C MCVEETY - Department of Neurology, Yale School of Medicine, New Haven, CT, United States
A SICKLICK - Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, United States
D MOALLI - Lawrence and Memorial Hospital, Groton, CT, United States
P GRECO - St. Mary's Hospital, Waterbury, CT, United States
Resource Type: Journal article
Publication Details: Neurology, Vol.72(15), pp.1345-1351
DOI: 10.1212/WNL.0b013e3181a0fda3
PMID: 19365056
PMCID: PMC2677492
NLM abbreviation: Neurology
ISSN: 0028-3878
eISSN: 1526-632X
Publisher: Lippincott Williams & Wilkins; Hagerstown, MD
Language: English
Date published: 2009
Academic Unit: Neurology
Record Identifier: 9984013163802771

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