Boron Triiodide-Mediated Reduction of Nitroarenes Using Borohydride Reagents

Andrej Ćorković; Thomas Chiarella; Florence J Williams

doi:10.1021/acs.orglett.3c03257

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Boron Triiodide-Mediated Reduction of Nitroarenes Using Borohydride Reagents

Journal article

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Boron Triiodide-Mediated Reduction of Nitroarenes Using Borohydride Reagents

Andrej Ćorković, Thomas Chiarella and Florence J Williams

Organic letters, Vol.25(49), pp.8787-8791

12/05/2023

DOI: 10.1021/acs.orglett.3c03257

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Abstract

The reduction of nitroarenes using KBH4 and I2 is described. BI3 is generated in situ and was shown to be the active reductant. Conditions were optimized for BI3 generation and then applied to a wide range of nitroarenes, including traditionally challenging substrates. The method constitutes a practical reduction option which produces low-toxicity boric acid and potassium iodide upon workup.

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Details

Title: Subtitle: Boron Triiodide-Mediated Reduction of Nitroarenes Using Borohydride Reagents
Creators: Andrej Ćorković - University of Iowa
Thomas Chiarella - University of Iowa
Florence J Williams - University of Iowa
Resource Type: Journal article
Publication Details: Organic letters, Vol.25(49), pp.8787-8791
DOI: 10.1021/acs.orglett.3c03257
eISSN: 1523-7052
Publisher: American Chemical Society
Grant note: DOI: 10.13039/100000165, name: Division of Chemistry, award: CHE 2239556; DOI: 10.13039/100008893, name: University of Iowa
Language: English
Date published: 12/05/2023
Academic Unit: Iowa Neuroscience Institute; Chemistry
Record Identifier: 9984527749702771

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