Journal article
Both Serum HIV Type 1 RNA Levels and CD4+Lymphocyte Counts Predict Clinical Outcome in HIV Type 1-Infected Subjects with 200 to 500 CD4+Cells per Cubic Millimeter
AIDS research and human retroviruses, Vol.16(7), pp.645-653
05/2000
DOI: 10.1089/088922200308873
PMID: 10791875
Abstract
To evaluate HIV-1 RNA and CD4+ cell responses to therapy as predictors of clinical progression and to evaluate levels and trends of these markers prior to clinical failure, HIV-1 RNA measurements were retrospectively obtained on subjects who progressed to AIDS or death and a random sample of subjects who did not. Samples were taken from AIDS Clinical Trials Group Study 175, a randomized trial comparing nucleoside analog therapies in subjects with CD4+ cell counts of between 200 and 500 cells/mm3. HIV-1 RNA and CD4+ cell count independently predicted clinical progression. Risk of subsequent progression is best captured by the change to the last measured value for CD4+ cell count and the area under the curve minus baseline, a measure of viral replication over time, for HIV-1 RNA. Subjects who failed had lower CD4+ cell counts, greater rates of CD4+ cell decline, and higher HIV-1 RNA levels, but not greater rates of HIV-1 RNA increase than subjects who did not. Subjects who maintained more than 200 CD4+ cells/mm3 and fewer than 10,000 copies of HIV-1 RNA per milliliter had low risk of progression. During the first few months of therapy, treatments are best monitored by regular HIV-1 RNA and less frequent CD4+ cell measurements. Thereafter, both markers should be monitored on a similar schedule to identify rapidly declining CD4+ cell counts, or adverse levels of either. These results further delineate the prognostic significance of HIV-1 RNA and CD4+ cell count and should help to better define their utility in the practice setting.
Details
- Title: Subtitle
- Both Serum HIV Type 1 RNA Levels and CD4+Lymphocyte Counts Predict Clinical Outcome in HIV Type 1-Infected Subjects with 200 to 500 CD4+Cells per Cubic Millimeter
- Creators
- Soyeon KimMichael D HughesScott M HammerJ. Brooks JacksonVictor DeGruttolaDavid A Katzenstein
- Resource Type
- Journal article
- Publication Details
- AIDS research and human retroviruses, Vol.16(7), pp.645-653
- DOI
- 10.1089/088922200308873
- PMID
- 10791875
- ISSN
- 0889-2229
- eISSN
- 1931-8405
- Language
- English
- Date published
- 05/2000
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984047741002771
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