Journal article
Brachyury downstream notochord differentiation in the ascidian embryo
Genes & development, Vol.13(12), pp.1519-1523
06/15/1999
DOI: 10.1101/gad.13.12.1519
PMCID: PMC316807
PMID: 10385620
Abstract
The ascidian tadpole represents the most simplified chordate body
plan. It contains a notochord composed of just 40 cells, but as in
vertebrates
Brachyury
is essential for notochord
differentiation. Here, we show that the misexpression of the
Brachyury
gene (
Ci-Bra
) of
Ciona intestinalis
is sufficient to transform endoderm into notochord. Subtractive
hybridization screens were conducted to identify potential
Brachyury
target genes that are induced upon
Ci-Bra
misexpression. Of 501 independent cDNA clones that were surveyed, 38
were specifically expressed in notochord cells. These potential
Ci-Bra
downstream genes appear to encode a broad spectrum
of divergent proteins associated with notochord formation.
Details
- Title: Subtitle
- Brachyury downstream notochord differentiation in the ascidian embryo
- Creators
- Hiroki Takahashi - Department of Zoology, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan ; Division of Genetics, Department of Molecular and Cellular Biology, University of California at Berkeley, Berkeley, California 94720 USA; Department of Biology, University of California at San Diego, La Jolla, California 92093-0347 USAKohji Hotta - Department of Zoology, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan ; Division of Genetics, Department of Molecular and Cellular Biology, University of California at Berkeley, Berkeley, California 94720 USA; Department of Biology, University of California at San Diego, La Jolla, California 92093-0347 USAAlbert Erives - Department of Zoology, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan ; Division of Genetics, Department of Molecular and Cellular Biology, University of California at Berkeley, Berkeley, California 94720 USA; Department of Biology, University of California at San Diego, La Jolla, California 92093-0347 USAAnna Di Gregorio - Department of Zoology, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan ; Division of Genetics, Department of Molecular and Cellular Biology, University of California at Berkeley, Berkeley, California 94720 USA; Department of Biology, University of California at San Diego, La Jolla, California 92093-0347 USARobert W Zeller - Department of Zoology, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan ; Division of Genetics, Department of Molecular and Cellular Biology, University of California at Berkeley, Berkeley, California 94720 USA; Department of Biology, University of California at San Diego, La Jolla, California 92093-0347 USAMichael Levine - Department of Zoology, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan ; Division of Genetics, Department of Molecular and Cellular Biology, University of California at Berkeley, Berkeley, California 94720 USA; Department of Biology, University of California at San Diego, La Jolla, California 92093-0347 USANori Satoh - Department of Zoology, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan ; Division of Genetics, Department of Molecular and Cellular Biology, University of California at Berkeley, Berkeley, California 94720 USA; Department of Biology, University of California at San Diego, La Jolla, California 92093-0347 USA
- Resource Type
- Journal article
- Publication Details
- Genes & development, Vol.13(12), pp.1519-1523
- Publisher
- Cold Spring Harbor Laboratory Press
- DOI
- 10.1101/gad.13.12.1519
- PMID
- 10385620
- PMCID
- PMC316807
- ISSN
- 0890-9369
- eISSN
- 1549-5477
- Language
- English
- Date published
- 06/15/1999
- Academic Unit
- Biology
- Record Identifier
- 9984217415902771
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