Brain Abnormalities in Bipolar Disorder Detected by Quantitative T1ρ Mapping

Casey P Johnson; Robin L Follmer; Ipek Oguz; Lois A Warren; Gary E Christensen; Jess G Fiedorowicz; Vincent A Magnotta; John A Wemmie

doi:10.1038/mp.2014.157

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Brain Abnormalities in Bipolar Disorder Detected by Quantitative T1ρ Mapping

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Brain Abnormalities in Bipolar Disorder Detected by Quantitative T1ρ Mapping

Casey P Johnson, Robin L Follmer, Ipek Oguz, Lois A Warren, Gary E Christensen, Jess G Fiedorowicz, Vincent A Magnotta and John A Wemmie

Molecular psychiatry, Vol.20(2), pp.201-206

02/2015

DOI: 10.1038/mp.2014.157

PMCID: PMC4346383

PMID: 25560762

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Abstract

Abnormal metabolism has been reported in bipolar disorder, however these studies have been limited to specific regions of the brain. To investigate whole-brain changes potentially associated with these processes, we applied a magnetic resonance imaging technique novel to psychiatric research, quantitative mapping of T1 relaxation in the rotating frame (T1ρ). This method is sensitive to proton chemical exchange, which is affected by pH, metabolite concentrations, and cellular density with high spatial resolution relative to alternative techniques such as magnetic resonance spectroscopy and positron emission tomography. Study participants included 15 patients with bipolar I disorder in the euthymic state and 25 normal controls balanced for age and gender. T1ρ maps were generated and compared between the bipolar and control groups using voxel-wise and regional analyses. T1ρ values were found to be elevated in the cerebral white matter and cerebellum in the bipolar group. However, volumes of these areas were normal as measured by high-resolution T1- and T2-weighted magnetic resonance imaging. Interestingly, the cerebellar T1ρ abnormalities were normalized in participants receiving lithium treatment. These findings are consistent with metabolic or microstructural abnormalities in bipolar disorder and draw attention to roles of the cerebral white matter and cerebellum. This study highlights the potential utility of high-resolution T1ρ mapping in psychiatric research.

Details

Title: Subtitle: Brain Abnormalities in Bipolar Disorder Detected by Quantitative T1ρ Mapping
Creators: Casey P Johnson - Veteran Affairs Hospital Center, Iowa City, IA
Robin L Follmer - Veteran Affairs Hospital Center, Iowa City, IA
Ipek Oguz - Veteran Affairs Hospital Center, Iowa City, IA
Lois A Warren - Veteran Affairs Hospital Center, Iowa City, IA
Gary E Christensen - Veteran Affairs Hospital Center, Iowa City, IA
Jess G Fiedorowicz - Veteran Affairs Hospital Center, Iowa City, IA
Vincent A Magnotta - Veteran Affairs Hospital Center, Iowa City, IA
John A Wemmie - Veteran Affairs Hospital Center, Iowa City, IA
Resource Type: Journal article
Publication Details: Molecular psychiatry, Vol.20(2), pp.201-206
DOI: 10.1038/mp.2014.157
PMID: 25560762
PMCID: PMC4346383
NLM abbreviation: Mol Psychiatry
ISSN: 1359-4184
eISSN: 1476-5578
Language: English
Date published: 02/2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Molecular Physiology and Biophysics; Psychiatry; Epidemiology; Iowa Neuroscience Institute; Radiation Oncology; Radiation Research Laboratory; Neurosurgery; Internal Medicine
Record Identifier: 9984003947902771

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