Journal article
Brain Developmental Trajectories in Children and Young Adults with Isolated Cleft Lip and/or Cleft Palate
Developmental neuropsychology, Vol.46(4), pp.314-326
07/2021
DOI: 10.1080/87565641.2021.1946691
PMCID: PMC8814052
PMID: 34348063
Abstract
The present study evaluated brain development in persons with isolated cleft lip and/or cleft palate (iCL/P) compared to unaffected controls using an accelerated longitudinal design. A sample of 134 males and females, ages 7-27 years, with iCL/P (184 observations, total) was compared to 144 unaffected controls (208 evaluations, total) on Wechsler Index scores and volumetric data from structural MRI scans. Boys with isolated cleft palate had verbal IQ 15.5 points lower than perceptual IQ; a clinically significant difference. Participants with iCL/P had differential growth trajectories of regional cerebrum matter and consistently lower volumes of cerebellar gray matter and subcortical matter.
Details
- Title: Subtitle
- Brain Developmental Trajectories in Children and Young Adults with Isolated Cleft Lip and/or Cleft Palate
- Creators
- Emily Kuhlmann - University of Iowa College of EducationEllen van der Plas - University of Iowa Carver College of MedicineEric Axelson - University of Iowa Carver College of MedicineAmy L Conrad - University of Iowa Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- Developmental neuropsychology, Vol.46(4), pp.314-326
- DOI
- 10.1080/87565641.2021.1946691
- PMID
- 34348063
- PMCID
- PMC8814052
- NLM abbreviation
- Dev Neuropsychol
- ISSN
- 8756-5641
- eISSN
- 1532-6942
- Publisher
- Routledge
- Grant note
- DOI: 10.13039/100000002, name: the National Institutes of Health; DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences, award: UL1TR002537; DOI: 10.13039/100000072, name: National Institute of Dental and Craniofacial Research, award: DE024511, DEO14399; name: Office of the Director, National Institutes of Health, award: 1S10OD02502501-01
- Language
- English
- Electronic publication date
- 08/04/2021
- Date published
- 07/2021
- Academic Unit
- Psychiatry; Pediatric Psychology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
- Record Identifier
- 9984115451502771
Metrics
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