Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory

Lara C Foland-Ross; Gabby Tong; Nelly Mauras; Allison Cato; Tandy Aye; Michael Tansey; Neil H White; Stuart A Weinzimer; Kimberly Englert; Hanyang Shen; Paul K Mazaika; Allan L Reiss; Diabetes Research in Children Network (DirecNet)

doi:10.2337/db20-0123

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Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory

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Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory

Lara C Foland-Ross, Gabby Tong, Nelly Mauras, Allison Cato, Tandy Aye, Michael Tansey, Neil H White, Stuart A Weinzimer, Kimberly Englert, Hanyang Shen, …

Diabetes (New York, N.Y.), Vol.69(8), pp.1770-1778

08/2020

DOI: 10.2337/db20-0123

PMCID: PMC7372069

PMID: 32471809

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https://doi.org/10.2337/db20-0123View

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Abstract

Glucose is a primary fuel source to the brain, yet the influence of dysglycemia on neurodevelopment in children with type 1 diabetes remains unclear. We examined brain activation using functional MRI in 80 children with type 1 diabetes (mean ± SD age 11.5 ± 1.8 years; 46% female) and 47 children without diabetes (control group) (age 11.8 ± 1.5 years; 51% female) as they performed a visuospatial working memory (N-back) task. Results indicated that in both groups, activation scaled positively with increasing working memory load across many areas, including the frontoparietal cortex, caudate, and cerebellum. Between groups, children with diabetes exhibited reduced performance on the N-back task relative to children in the control group, as well as greater modulation of activation (i.e., showed greater increase in activation with higher working memory load). Post hoc analyses indicated that greater modulation was associated in the diabetes group with better working memory function and with an earlier age of diagnosis. These findings suggest that increased modulation may occur as a compensatory mechanism, helping in part to preserve working memory ability, and further, that children with an earlier onset require additional compensation. Future studies that test whether these patterns change as a function of improved glycemic control are warranted.

Brain - physiopathology

Child

Cognition - physiology

Diabetes Mellitus, Type 1 - physiopathology

Female

Humans

Magnetic Resonance Imaging - methods

Male

Memory, Short-Term - physiology

Details

Title: Subtitle: Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory
Creators: Lara C Foland-Ross - Stanford University
Gabby Tong - Stanford University
Nelly Mauras - Nemours Children's Health System
Allison Cato - Nemours Children's Health System
Tandy Aye - Stanford University
Michael Tansey - University of Iowa
Neil H White - St. Louis Children's Hospital
Stuart A Weinzimer - Yale University
Kimberly Englert - Nemours Children's Health System
Hanyang Shen - Stanford University
Paul K Mazaika - Stanford University
Allan L Reiss - Stanford University
Diabetes Research in Children Network (DirecNet)
Resource Type: Journal article
Publication Details: Diabetes (New York, N.Y.), Vol.69(8), pp.1770-1778
DOI: 10.2337/db20-0123
PMID: 32471809
PMCID: PMC7372069
NLM abbreviation: Diabetes
ISSN: 0012-1797
eISSN: 1939-327X
Grant note: UL1 TR003142 / NCATS NIH HHS U54 HD087011 / NICHD NIH HHS R01 HD078463 / NICHD NIH HHS UL1 TR001085 / NCATS NIH HHS U10 HD041906 / NICHD NIH HHS UL1 TR002345 / NCATS NIH HHS UL1 TR000448 / NCATS NIH HHS U10 HD041918 / NICHD NIH HHS U10 HD041915 / NICHD NIH HHS U10 HD041908 / NICHD NIH HHS UL1 TR001863 / NCATS NIH HHS U10 HD056526 / NICHD NIH HHS P30 DK045735 / NIDDK NIH HHS
Language: English
Date published: 08/2020
Academic Unit: Endocrinology and Diabetes; Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984354046202771

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