Journal article
Brain MRI Lesion Load at 1.5T and 3T versus Clinical Status in Multiple Sclerosis
Journal of neuroimaging, Vol.21(2), pp.e50-e56
04/2011
DOI: 10.1111/j.1552-6569.2009.00449.x
PMCID: PMC3043123
PMID: 19888926
Abstract
BACKGROUND/PURPOSE
To assess correlation between brain lesions and clinical status with 1.5T and 3T magnetic resonance imaging (MRI).
METHODS
Brain MRI fluid-attenuated inversion-recovery (FLAIR) sequences were performed in 32 multiple sclerosis (MS) patients. Expanded Disability Status Scale (EDSS) score (mean +/- standard deviation) was 2 +/- 2.0 (range 0-8), disease duration 9.3 +/- 8.0 (range .8-29) years.
RESULTS
FLAIR lesion volume (FLLV) at 3T was higher than at 1.5T (P = .01). Correlation between 1.5T FLLV and EDSS score was poor, while 3T FLLV correlated moderately and significantly (r(s) = .39, P = .03). When controlling for age and depression, correlations between FLLV and cognitive measures were significant at 1.5T for the Judgment of Line Orientation test (JLO) (r(s) = -.44, P = .05), the Symbol Digit Modalities Test (SDMT) (r(s) = -.49, P = .02), and the California Verbal Learning Test Delayed Free Recall (CVLT DR) (r(s) = -.44, P = .04). Correlations at 3T were also significant for these tests, but of greater magnitude: JLO (r(s) = -.70, P = .0005), SDMT (r(s) = -.73, P = .0001), CVLT DR (r(s) = -.061, P = .003). Additional significant correlations obtained only at 3T included the 2 second-paced auditory serial addition test (r(s) = -.55, P = .01), the Brief Visuospatial Memory Test-Delayed Free Recall (r(s) = -.56, P = .007), and the California Verbal Learning Test Total Recall (r(s) = -.42, P = .05).
CONCLUSION
MRI at 3T may boost sensitivity and improve validity in MS brain lesion assessment.
Details
- Title: Subtitle
- Brain MRI Lesion Load at 1.5T and 3T versus Clinical Status in Multiple Sclerosis
- Creators
- James M. Stankiewicz - Brigham and Women's HospitalBonnie I. Glanz - Brigham and Women's HospitalBrian C. Healy - Brigham and Women's HospitalAshish Arora - University at Buffalo, State University of New YorkMohit Neema - Brigham and Women's HospitalRalph H. B. Benedict - University at Buffalo, State University of New YorkZachary D. Guss - Brigham and Women's HospitalShahamat Tauhid - Brigham and Women's HospitalGuy J. Buckle - Brigham and Women's HospitalMaria K. Houtchens - Brigham and Women's HospitalSamia J. Khoury - Brigham and Women's HospitalHoward L. Weiner - Brigham and Women's HospitalCharles R. G. Guttmann - Brigham and Women's HospitalRohit Bakshi - Brigham and Women's Hospital
- Resource Type
- Journal article
- Publication Details
- Journal of neuroimaging, Vol.21(2), pp.e50-e56
- Publisher
- Wiley
- DOI
- 10.1111/j.1552-6569.2009.00449.x
- PMID
- 19888926
- PMCID
- PMC3043123
- ISSN
- 1051-2284
- eISSN
- 1552-6569
- Number of pages
- 7
- Grant note
- 1R01NS055083-01 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01NS055083 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) RG3705A1; RG3798A2 / National Multiple Sclerosis Society
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Psychiatry
- Record Identifier
- 9984627227502771
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